Itou 2011.

Methods	Randomised clinical trial, Japan
Participants	36 hospitalised adults with chronic liver disease and oesophageal and gastric varices, at nutritional risk defined by trialist Male:Female = 29:7 Mean age: 65.9 years Exclusion criteria: Ascites and renal failure
Interventions	Experimental group: Oral supplement consisting of a 200 kcal CalorieMate Jelly(n = 18) Control group: No intervention (no meal)(n = 18)
Outcomes	Physical symptoms (thirst, light‐headedness, nausea, headache, palpitation and cold sweat) and mental symptoms(hunger, hypodynamia, fatigue, poor thinking, poor concentration, irritability)
Study dates	Not stated
Notes	The authors were contacted on 9.12.15 by email: Itou74m@med.kurume‐u.ac.jp. We received no reply.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not described
Allocation concealment (selection bias)	Unclear risk	Not described
Blinding of participants and personnel (performance bias) All outcomes	High risk	Participants were not blinded.
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Endoscopists were blinded.
Incomplete outcome data (attrition bias) All outcomes	Low risk	No dropouts
Selective reporting (reporting bias)	Unclear risk	No protocol could be obtained and the trial did not report on all‐cause mortality or serious adverse event.
For‐profit bias	Low risk	The study was supported, in part, by a Grant‐in‐Aid for Young Scientists (B) (No.22790874 to T.K.) and a Grant‐in‐Aid for Scientific Research (C)(No. 21590865 to M.S.) from the Ministry of Education, Culture, Sports, Science and Technology of Japan, and by Health and Labour Sciences Research Grants for Research on Hepatis from the Ministry of Health, Labour and Welfare of Japan.
Other bias	Low risk	The trial appeared to be free of other components that could put it at risk of bias.