Jimenez 1995c.

Methods	Randomised clinical trial, Spain
Participants	75 hospitalised adults, at nutritional risk due to low levels of albumin or body weight below 95% of ideal weight
Interventions	Experimental group 1: 59.1 g amino acids + 694 non‐protein calories (glucose)(n = 20) Experimental group 2: 57.9 g amino acids + 600 non‐protein calories (glycerol)(n = 20) Experimental group 3: 56.6 g amino acids + 590 non‐protein calories (sorbitol‐xylitol)(n = 20) Control group: Conventional infusion therapy (5% glucose)(n = 15)
Outcomes	All‐cause mortality, complications, plasma concentrations
Study dates	Not stated
Notes	Same as Jimenez 1995a and Jimenez 1995b. We only report experimental group 3 vs control here. We contacted the authors on 13th December 2015 by email: fjavierjimenez@telefonica.net. We received no reply.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not described
Allocation concealment (selection bias)	Unclear risk	Not described
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Not described
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Not described
Incomplete outcome data (attrition bias) All outcomes	Low risk	There were no drop‐outs.
Selective reporting (reporting bias)	Low risk	All‐cause mortality and serious adverse events were assessed.
For‐profit bias	Unclear risk	The trial was funded by the Spanish Ministry of Health.
Other bias	Low risk	The trial appeared to be free of other components that could put it at risk of bias.