Jin 1999a.
Methods | Randomised clinical trial, China | |
Participants | 92 hospitalised adults diagnosed with adenocarcinoma of the GI tract deemed operable by a consultant surgeon, at nutritional risk due to serum albumin < 30 g/L or a recent weight loss of > 10% body weight Male:Female = 58:34 Mean age = 57 years Exclusion:congestive heart failure, obstructive lung disease, metabolic diseases, clinically‐evident cirrhotic liver disease or renal disease |
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Interventions | Experimental group 1: Parenteral nutrition: Preoperative PN provided 35 kcal/kg a day. Non‐protein caloric content was divided between dextrose (60%) and lipids (40%) (Intralipid; Kabi Pharmacia, Sweden). Crystalline amino acids (7% Vamin; Kabi Pharmacia, Sweden) were provided at a calorie:nitrogen ratio of 150:1 g of nitrogen (0.23 g of nitrogen a kilogram a day). Each day, the nutrient mixture, which was prepared in ethyl vinyl acetate bags, was infused through a subclavian polyurethane catheter over 24 hrs by an infusion pump. The catheter was inserted using a strict aseptic procedure in the operating room.(n = 23) Control group 1: No intervention(n = 23) |
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Outcomes | Weight, complications, postoperative mortality and nutritional parametres including serum albumin (g/L), serum transferrin (g/L), nitrogen balance (g/L) | |
Study dates | Not stated | |
Notes | We could obtain no contact information for the authors. Same trial as Jin 1999b but with the experimental and control group that did not received chemotherapy. | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Not described |
Allocation concealment (selection bias) | Unclear risk | Not described |
Blinding of participants and personnel (performance bias) All outcomes | High risk | Participants and personnel were not blinded. |
Blinding of outcome assessment (detection bias) All outcomes | High risk | Outcome assessors were not blinded. |
Incomplete outcome data (attrition bias) All outcomes | Low risk | All participants completed the study. |
Selective reporting (reporting bias) | Low risk | The protocol could not be obtained, but the trial reported on serious adverse events and mortality. |
For‐profit bias | Unclear risk | It was unclear how the trial was funded. |
Other bias | Low risk | The trial appeared to be free of other components that could put it at risk of bias. |