Li 1997.
| Methods | Randomised clinical trial, China | |
| Participants | 21 hospitalised adults diagnosed with COPD and critically ill according to the following criteria: diagnosed with pulmonary heart disease, pulmonary function test is FEV1/FVC < 70%, less than 10% increase of FEVI/FVC after using bronchus spasmolytic, arterial blood gas analysis: PaO2 < 60 mmHg and (or) PaCO2 > 50 mmHg. The participants were also diagnosed with malnutrition according to following criteria: 1. referred to the multiparameter nutritional index scoring system (MNI) by Laeabn JP, considering body weight (WT); 2. triceps skinfold (TSF); 3. mid‐arm muscle circumference (MAMC); 4. creatinine increased with normal liver and kidney function, at nutritional risk according to the trialist. Male:Female = 19:2 Mean age = 68 years Exclusion criteria: asthma, neuromuscular disease, chronic gastrointestinal malabsorption, diabetes, thyroid disease and cancer |
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| Interventions | Experimental group: Parenteral nutrition: 30 Kcal/ Kg each day, nitrogen 0.20˜ 0.25g/kg by amino acid, 35%˜45% calorie by fat emulsion. Treatment course was 14 days.(n = 10) Control group: Intravenous infusion: 100˜200Kcal glucose each day for 14 days.(n = 11) Co‐interventions: Food nutrition: hospital‐made nutrition diet(protein 17%, fat 30% and carbohydrate 53%). |
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| Outcomes | Serum albumin concentration, serum TRF, pre‐albumin concentration, CHI, SFAA. | |
| Study dates | Not stated | |
| Notes | We contacted the authorby phone 3 times, but he had no time to answer. | |
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Unclear risk | Not described |
| Allocation concealment (selection bias) | Unclear risk | Not described |
| Blinding of participants and personnel (performance bias) All outcomes | High risk | Participants and personnel were not blinded. |
| Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Not described |
| Incomplete outcome data (attrition bias) All outcomes | Unclear risk | The number of participants with incomplete data was not reported. |
| Selective reporting (reporting bias) | Unclear risk | No protocol could be obtained and the trial did not report on all‐cause mortality or serious adverse event. |
| For‐profit bias | Unclear risk | It was unclear how the trial was funded. |
| Other bias | Low risk | The trial appeared to be free of other components that could put it at risk of bias. |