Mattox 1992.

Methods	Randomised clinical trial, USA
Participants	18 hospitalised adults admitted for rectal carcinoma surgery, at nutritional risk due to major surgery. Male:Female = not stated Mean age = not stated Exclusion criteria: none stated
Interventions	Experimental group: Lipid‐based TPN(n = 9) Control group: Intravenous fluid (n = 9)
Outcomes	Tumour protein synthesis
Study dates	Not stated
Notes	We contacted the author on 13th December 2015 by email: mattoxtw@moffitt.usf.edu. We received no reply.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not described
Allocation concealment (selection bias)	Unclear risk	Not described
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Not described
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Not described
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	The reasons for dropouts were unclear.
Selective reporting (reporting bias)	Unclear risk	No protocol could be obtained, and the trial did not report on all‐cause mortality or serious adverse events.
For‐profit bias	Unclear risk	It was unclear how the trial was funded.
Other bias	Low risk	The trial appeared to be free of other components that could put it at risk of bias.