Neuvonen 1984.
Methods | Randomised clinical trial, Finland | |
Participants | 19 hospitalised adults undergoing major abdominal surgery and having 3 out of the following 7 criteria: weight loss > 5% a month, the weight‐for‐height index, arm muscle circumference, triceps skinfold thickness or creatinine‐height index was < 90% of normal or if the serum albumin concentration was < 32 g/l or the serum pre‐albumin concentration was < 0.08 g/l, at nutritional risk due major abdominal surgery Male:Female = 12:7 Mean age = 55 years Exclusion criteria: Not stated |
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Interventions | Experimental group: TPN was started 10 days before the planned operation. The participants received nutrition through a central venous catheter which included 1 ‐ 2 g/kg/day amino acids, 150 ‐ 200 kcal/1gN (glucose and fat), 40 ‐ 60 ml/kg water together with the necessary minerals and vitamins(n = 9) Control group: No treatment(n = 10) |
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Outcomes | Leucocyte counts, mitogen‐ and antigen‐induced lymphocyte proliferative responses, complications, mortality | |
Study dates | Not stated | |
Notes | We found no contact information for the authors. | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Not described |
Allocation concealment (selection bias) | Unclear risk | Not described |
Blinding of participants and personnel (performance bias) All outcomes | High risk | Participants and personnel were not blinded due to the nature of the intervention. |
Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Not described |
Incomplete outcome data (attrition bias) All outcomes | Low risk | There were no dropouts. |
Selective reporting (reporting bias) | Low risk | No protocol could be obtained, but the trial reported serious adverse event and mortality. |
For‐profit bias | Unclear risk | It was unclear how the trial was funded. |
Other bias | Low risk | The trial appeared to be free of other components that could put it at risk of bias. |