Song 1993.
Methods | Randomised clinical trial, China | |
Participants | 25 hospitalised adults with COPD and infection, PaO2 < 8 kPa, or PaCO2 > 6.7 kPa, at nutritional risk due to trialist characterising them as malnourished. Male:Female = 23:2 Mean age = 60.3 years Exclusion criteria: diabetes, hyperthyroidism or other endocrine and metabolic diseases |
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Interventions | Experimental group: Received parenteral nutrition in the form of amino acids injection (5% Nutrisol‐S) 500 ml (Green Cross, Japan) and lipid emulsion (Intralipid: (1000 ml Intralipid contains rectification soybean oil 100 g, glycerinum 22.5 g rectification lecithin 12 g, PH 8.0, 4602.4 kJ/kg)) 500 ml (Sino‐Swed Pharmaceutical Corp. Ltd. China) for intravenous drip, once daily, for 10 to 20 days (10 of the participants were over 15 days). (n = 23) Control group: standard diet(n = 23) Co‐intervention: persistent low‐flow oxygen inspiration and anti‐infection, anti‐asthmatic and antitussive and standard diet |
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Outcomes | All‐cause mortality, NEFA, ABG, serum amino acid | |
Study dates | Not stated | |
Notes | We tried and failed to contact the authors by phone. | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Not described |
Allocation concealment (selection bias) | Unclear risk | Not described |
Blinding of participants and personnel (performance bias) All outcomes | High risk | Participants and personnel were not blinded. |
Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Not described |
Incomplete outcome data (attrition bias) All outcomes | Unclear risk | The number of participants with incomplete data was not reported. |
Selective reporting (reporting bias) | Low risk | No protocol could be obtained but all‐cause mortality was reported. |
For‐profit bias | Unclear risk | It was unclear how the trial was funded. |
Other bias | Low risk | The trial appeared to be free of other components that could put it at risk of bias. |