Skip to main content
. 2017 May 19;2017(5):CD011598. doi: 10.1002/14651858.CD011598.pub2

Williams 1983.

Methods Randomised clinical trial, UK
Participants 14 hospitalised adults with squamous cell carcinoma of the oesophagus, at nutritional risk according to the trialist
Exclusion criteria: unable to swallow their saliva at presentation
Interventions Experimental group: fine‐bore enteral feeding (2400 ml of Isocal/24 hrs. (n = 7) Each litre = 33 g protein, 42 g of fat, 125 g carbohydrate) for 6 weeks
 Control group: no intervention (n = 7)
Co‐interventions: standard ward diet
Outcomes Potassium, weight change
Study dates Not stated
Notes The trial found that very few of the experimental group had received the standard ward diet, because of the supplementary enteral feeding.
The trial was terminated before it was finished, due to an increased effect of the experimental group. We contacted the authors by email:john.fenwick@ccotrust.nhs.uk. We received no reply.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Not described
Allocation concealment (selection bias) Unclear risk Not described
Blinding of participants and personnel (performance bias) 
 All outcomes High risk Not blinded. Only the experimental group received tube‐feeding.
Blinding of outcome assessment (detection bias) 
 All outcomes Unclear risk Not described
Incomplete outcome data (attrition bias) 
 All outcomes Unclear risk The number of participants with incomplete data was not reported.
Selective reporting (reporting bias) Unclear risk No protocol could be obtained and the trial did not report serious adverse events or mortality.
For‐profit bias Unclear risk It was unclear how the trial was funded.
Other bias Low risk The trial appeared to be free of other components that could put it at risk of bias.