Wood 1989a.
Methods | Randomised clinical trial, USA | |
Participants | 55 hospitalised adult men undergoing routine major surgery, at nutritional risk due to major surgery Male:Female = 55:0 Mean age = 54 years Exclusion criteria: none stated |
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Interventions | Experimental group 1: TPN (90 g of crystalline amino acids, 3000 calories as glucose a day) from 2 weeks prior to surgery until 1 week after surgery (n = 10)
Experimental group 2: parenteral nutrition 90 g amino acids a day (n = 15) Experimental group 3: parenteral nutrition: peripheral parenteral nutrition (90 g amino acids plus 1600 calories, 60% as fat a day)(n =15) Control group: treatment as usual (100 g glucose) (n = 15) |
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Outcomes | Nitrogen balance, maintenance of body cell mass, serum albumin levels, exercise capacity | |
Study dates | Not stated | |
Notes | Group 1 could not be used in the analysis, since this group was not properly randomised (they had to have a certain degree of malnutrition, before being randomised to this group). | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Not described |
Allocation concealment (selection bias) | Unclear risk | Not described |
Blinding of participants and personnel (performance bias) All outcomes | Unclear risk | Not described |
Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Not described |
Incomplete outcome data (attrition bias) All outcomes | Unclear risk | Not described |
Selective reporting (reporting bias) | Unclear risk | No protocol could be obtained, and the trial did not report mortality or serious adverse events. |
For‐profit bias | Low risk | The trial was funded by the Veterans Affairs Administration. |
Other bias | Low risk | The trial appeared to be free of other components that could put it at risk of bias. |