Zhao 2014.
Methods | Randomised clinical trial, China | |
Participants | 64 hospitalised adults with acute non‐lymphocytic leukaemia, at nutritional risk according to trialist indication Male:Female = not stated Mean age = 32.8 years Exclusion criteria: acute disease exacerbation; chronic diseases such as concomitant with diabetes, hypertension, liver and kidney dysfunction; concomitant with serious allergy and other immune system diseases; pregnant or lactating; within 6 months after surgery; end‐stage leukaemia |
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Interventions | Experimental group: Standard nutrition support provided to the participants with established nutrition risk (NRS‐2002 ≥ 3) during the next chemotherapy course. The participants should have high protein and high energy intake 3 days before and 1 week after chemotherapy, which was achieved with oral Enteral Nutritional Powder (TP) 40 g.
The nutrition support protocol of “allowable intake inadequacy” of relatively lower energy (80% of required energy) should consist of oral Enteral Nutritional Powder (TP) 30 g, twice a day, as supplementation.(n = 32) Control group: Standard hospital diet(n = 32) |
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Outcomes | Prealbumin, haemoglobin, red blood cell, albumin, total protein, BMI | |
Study dates | Not stated | |
Notes | We had trouble understanding the language in this trial, hence limited descriptions. We contacted the authors on 25th September 2015 by email: zhuzhiming6542@sina.com. We received no reply. | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Not described |
Allocation concealment (selection bias) | Unclear risk | Not described |
Blinding of participants and personnel (performance bias) All outcomes | Unclear risk | Not described |
Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Not described |
Incomplete outcome data (attrition bias) All outcomes | Unclear risk | The number of participants with incomplete data was not reported. |
Selective reporting (reporting bias) | Unclear risk | No protocol could be obtained and the trial did not report all‐cause mortality or serious adverse events. |
For‐profit bias | Low risk | Trial was supported by the Creative Foundation of Navy General Hospital (CX201113). |
Other bias | Low risk | The trial appeared to be free of other components that could put it at risk of bias. |