Summary of findings 5.
Continuous glucose monitoring compared to intermittent glucose monitoring for women with pre‐existing diabetes
| Continuous glucose monitoring compared to intermittent glucose monitoring for women with pre‐existing diabetes | ||||||
| Patient or population: women with pre‐existing diabetes Setting: one study in Denmark, one study in the UK Intervention: continuous glucose monitoring Comparison: intermittent glucose monitoring | ||||||
| Outcomes | Anticipated absolute effects* (95% CI) | Relative effect (95% CI) | № of participants (studies) | Quality of the evidence (GRADE) | Comments | |
| Risk with intermittent glucose monitoring | Risk with continuous glucose monitoring | |||||
| Hypertensive disorders of pregnancy: pre‐eclampsia | Study population | RR 1.37 (0.52 to 3.59) | 225 (2 RCTs) | ⊕⊕⊝⊝ LOW 1 | ||
| 56 per 1000 | 76 per 1000 (29 to 199) | |||||
| Hypertensive disorders of pregnancy: gestational hypertension | Study population | (0 studies) | The included studies did not report this outcome. | |||
| Caesarean section | Study population | RR 1.00 (0.65 to 1.54) | 225 (2 RCTs) | ⊕⊝⊝⊝ VERY LOW 2 3 | ||
| 481 per 1000 | 481 per 1000 (313 to 741) | |||||
| Glycaemic control during/end of treatment: maternal HbA1c (%) | The mean maternal HbA1c was 6.4% | The mean maternal HbA1c with continuous glucose monitoring was 0.60 lower (0.91 lower to 0.29 higher) | 71 (1 RCT) | ⊕⊕⊕⊝ MODERATE 4 | ||
| Glycaemic control during/end of treatment: post‐prandial blood glucose | (0 studies) | The included studies did not report this outcome. | ||||
| Large‐for‐gestational age | Study population | RR 0.89 (0.41 to 1.92) | 221 (2 RCTs) | ⊕⊝⊝⊝ VERY LOW 3 5 | ||
| 410 per 1000 | 364 per 1000 (168 to 786) | |||||
| Perinatal mortality | Study population | RR 0.82 (0.05 to 12.61) | 71 (1 RCT) | ⊕⊕⊝⊝ LOW 1 | ||
| 31 per 1000 | 26 per 1000 (2 to 394) | |||||
| Preterm birth less than 37 weeks | Study population | RR 1.10 (0.63 to 1.94) | 228 (2 RCTs) | ⊕⊕⊝⊝ LOW 1 | ||
| 167 per 1000 | 183 per 1000 (105 to 323) | |||||
| Preterm birth less than 34 weeks' gestation | Study population | (0 studies) | The included studies did not report this outcome. | |||
| *The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: Confidence interval; RR: Risk ratio | ||||||
| GRADE Working Group grades of evidence High quality: We are very confident that the true effect lies close to that of the estimate of the effect Moderate quality: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different Low quality: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect Very low quality: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect | ||||||
1 Wide CI crossing the line of no effect, few events and small sample size.
2 Statistical heterogeneity (I² = 62%).
3 Wide CI crossing the line of no effect, and small sample size.
4 Small sample size.
5 Statistical heterogeneity (I² = 82%).