Summary of findings for the main comparison. Clonidine versus placebo for neonates receiving mechanical ventilation.

Clonidine versus placebo for neonates receiving mechanical ventilation
Patient or population: neonates receiving mechanical ventilation Settings: neonatal intensive care unit Intervention: clonidine vs placebo
Outcomes	Illustrative comparative risks* (95% CI)		Relative effect (95% CI)	Number of participants (studies)	Quality of the evidence (GRADE)	Comments
	Assumed risk	Corresponding risk
	Control	Clonidine vs placebo
All‐cause mortality during initial hospitalization	Study population		RR 0.69 (0.12 to 3.98)	112 (1 study)	⊕⊕⊝⊝ lowa	Downgraded for imprecision: 1 study identified with few events
*The basis for the assumed risk (e.g. median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: confidence interval; RR: risk ratio
GRADE Working Group grades of evidence High quality: Further research is very unlikely to change our confidence in the estimate of effect Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate Very low quality: We are very uncertain about the estimate

^aOne study and few events