Covariates |
Age in years at examination 7 MRI, mean±SD |
62.0±9.4 |
Male, n (%) |
958 (47.0%) |
APOE4 presence, n (%) |
469 (23.0%) |
Number of MSRB3 risk alleles |
0 alleles, n (%) |
1407 (69.0%) |
1 allele, n (%) |
587 (28.8%) |
2 alleles, n (%) |
44 (2.2%) |
Outcomes |
Total brain volume %, mean±SD |
79.3±3.5 |
Hippocampal volume %, mean±SD |
0.5±0.05 |
White matter hyperintensities %, median [Q1, Q3] |
0.05 [0.03, 0.1] |
Presence of brain infarcts, n (%) |
232 (11.4%) |
Incident dementia, n (%) |
116 (11.2%) |
Incident Alzheimer’s disease, n (%) |
91 (8.8%) |
Incident stroke, n (%) |
96 (4.9%) |