Table 2.

Associations of MSRB3 risk allele and MRI outcomes at Exam 7

Outcome	n	Measure of Association	Estimate [95% CI]	Adjusted p-value
Total brain volume	1,987	β	0.14 [–0.15, 0.42]	0.518
Hippocampal volume	1,977	β	–0.004 [–0.01, 0.001]	0.304
White matter hyperintensities	1,987	β	0.04 [–0.05, 0.13]	0.518
Presence of brain infarcts	2,038	OR	1.56 [1.16, 2.08]	0.022*
Incident dementia	1,032	HR	1.06 [0.70, 1.60]	0.931
Incident Alzheimer’s disease	1,032	HR	1.00 [0.62, 1.61]	0.997
Incident stroke	1,952	HR	1.44 [0.95, 2.19]	0.304

^*FDR < 0.05. OR, odds ratio; HR, hazard ratio. Adjusted for age, age squared (MRI outcomes), sex, and APOE4 presence.