Table 3.

APOE4 and MSRB3 risk allele interaction

Outcome	Measure of Association	Interaction nominal p-value	APOE4 Present (n = 469)			APOE4 Absent (n = 1,569)
			n	Estimate [95% CI]	Adjusted p-value	n	Estimate [95% CI]	Adjusted p-value
Total brain volume	β	0.170	455	–0.20 [–0.82, 0.42]	0.715	1,532	0.25 [–0.07, 0.57]	0.548
Hippocampal volume	β	0.519	455	–0.01 [–0.02, 0.004]	0.548	1,522	0.00 [–0.01, 0.003]	0.548
White matter hyperintensities	β	0.552	455	0.09 [–0.08, 0.27]	0.548	1,532	0.03 [–0.08, 0.13]	0.715
Presence of brain infarcts	OR	0.044	469	0.88 [0.45, 1.72]	0.715	1,569	1.84 [1.30, 2.60]	0.008*
Incident dementia	HR	0.387	234	1.34 [0.69, 2.58]	0.598	798	0.90 [0.52, 1.55]	0.715
Incident Alzheimer’s disease	HR	0.115	234	1.55 [0.78, 3.07]	0.548	798	0.66 [0.33, 1.33]	0.548
Incident stroke	HR	0.593	449	1.16 [0.52, 2.62]	0.715	1,503	1.53 [0.94, 2.50]	0.548

^*FDR < 0.05. OR, odds ratio; HR, hazard ratio. Adjusted for age, age squared (MRI outcomes), and sex.