Table 4.

FHS subjects, grouped according to CDR score, with analyzed MsrB3 immunoreactivity in the arteriolar walls of the hippocampal WM and the information on the presence of MSRB3 risk allele, APOE4, and vascular disease

Subject	Number of alleles		Arteriolosclerosis in hippocampus		Brain infarcts	History pathology		WM
	MSRB3 rs61921502 risk allele (G)	APOE4	Cortex	WM		Stroke or TIA	HTN
CDR 0–0.5
E	0	0	0	0	BG &WM	N	Y	WM gliosis
F	0	0	0	2+	Striatum, neocortex	N	Y	VWMD
A	1	0	0	2+	N	N	N	WM gliosis
G	0	0	0	1–2	OCC, BG, WM	N	Y	Some gliosis
CDR 1–3
B	1	1	0	1+	BG, WM	N	Y	WM gliosis; corpora amylacea
H	0	1	0	0	N	N	Y	Minimal gliosis
C	1	0	0	0	N	N	Y	VWMD in STG, PFC, OCC
I	0	0	0	1+	Temporal WM	N	N	VWMD
J	0	1	0	2+	Right motor cortex and lateral angle of the lateral ventricle	Y	Y	Large acute infarct in the right MCA territory
D	1	1	0	2+	N	N	Y	WM gliosis and macrophages in the hippocampus

*0 = none; 1+ = mild; 2+ = moderate; 3+ = severe. HTN, hypertension; VWMD, vascular white matter disease; BG, basal ganglia; STG, superior temporal gyrus; PFC, prefrontal cortex; OCC, occipital pole; CRBL, cerebellum; TIA, transient ischemic attack; MCA, middle cerebral artery. Analyzed hippocampi of subjects, divided according to Clinical Dementia Rating (CDR) score; subjects with CDR 1–3 have clinical dementia. Arteriolosclerosis of hippocampal cortex and white matter was graded by severity of disease on H&E sections from hippocampus, from 0 (none) to 2 + . Arteriolosclerosis of neocortex was also graded on H&E in some of the subjects. Infarcts and other vascular/ vascular- related pathology were recorded according to the neuropathology reports. History of stroke and/or hypertension was recorded according to the clinical histories available through brain bank or de-identified autopsy reports.