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. 2019 Mar 29;68(2):695–710. doi: 10.3233/JAD-181032

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Fig.6 — a) qPCR results for fold-change SPARC and fold change Hevin, resulted from whole lysate tissue of AD patients. AD-specific values were normalized to endogenous genes and control values. Although statistically insignificant, SPARC appears to be up- regulated and Hevin downregulated in AD. b) SPARC is upregulated and colocalized to pathological plaques in AD patients. After microdissection (via LCM) and RNA isolation, plaques areas reveal the most potent changes. qPCR results from LCM-cut tissue is compared to values from whole lysate treatment (right bars).