Table 3. Hazard Ratio (HR) estimates (95% CI) for baseline and lifetime alcohol intakes and PC.
| Men | Baseline alcohol | Lifetime alcohol | |||||||
| cases | PY | HR1 | 95%CI | cases | PY | HR2 | 95%CI | ||
| Continuous (12 g/day)3 | |||||||||
| 556 | 1,978,417 | 1.05 | (1.01, 1.09) | 429 | 1,460,432 | 1.06 | (1.02, 1.10) | ||
| ptrend | 0.02 | <0.01 | |||||||
| Categories (g/day) | |||||||||
| Ex-consumers | - | - | - | - | 24 | 61,485 | 1.78 | (0.75, 4.22) | |
| Non consumers | 40 | 131,552 | 1.23 | (0.84, 1.79) | 4 | 33,366 | 0.53 | (0.16, 1.74) | |
| 0.1 - 4.94 | 101 | 439,915 | 1.00 | (Ref) | 41 | 176,469 | 1.00 | (Ref) | |
| 5 - 14.9 | 132 | 532,427 | 0.99 | (0.76, 1.29) | 119 | 400,402 | 1.22 | (0.82, 1.81) | |
| 15 - 29.9 | 116 | 403,985 | 1.11 | (0.83, 1.47) | 116 | 389,206 | 1.26 | (0.84, 1.90) | |
| 30 - 59.9 | 104 | 345,443 | 1.10 | (0.82, 1.47) | 88 | 287,583 | 1.42 | (0.93, 2.17) | |
| ≥60 | 63 | 125,095 | 1.63 | (1.16, 2.29) | 37 | 111,921 | 1.77 | (1.06, 2.95) | |
| pWald5 | 0.03 | 0.23 | |||||||
| Women | Baseline alcohol | Lifetime alcohol | |||||||
| cases | PY | HR1 | 95%CI | cases | PY | HR2 | 95%CI | ||
| Continuous (12 g/day)3 | |||||||||
| 727 | 4,660,980 | 1.04 | (0.97, 1.12) | 537 | 3,486,009 | 1.01 | (0.88, 1.14) | ||
| ptrend | 0.28 | 0.90 | |||||||
| Categories (g/day) | |||||||||
| Ex-consumers | - | - | - | - | 31 | 176,499 | 1.07 | (0.54, 2.11) | |
| Non consumers | 127 | 799,607 | 0.98 | (0.78, 1.23) | 63 | 495,243 | 0.72 | (0.47, 1.10) | |
| 0.1 - 4.94 | 280 | 1,852,494 | 1.00 | (Ref) | 210 | 1,296,401 | 1.00 | (Ref) | |
| 5 - 14.9 | 187 | 1,257,465 | 1.00 | (0.82, 1.21) | 165 | 1,052,229 | 1.06 | (0.85, 1.34) | |
| 15 - 29.9 | 80 | 487,565 | 1.11 | (0.86, 1.44) | 59 | 382,037 | 1.16 | (0.85, 1.59) | |
| ≥30 | 53 | 263,849 | 1.16 | (0.85, 1.59) | 9 | 83,601 | 0.93 | (0.47, 1.85) | |
| pWald5 | 0.68 | 0.79 | |||||||
Models for baseline alcohol intake were stratified by center and age at recruitment. Systematic adjustment was undertaken for smoking intensity, physical activity level, educational attainment, diabetes status, BMI, height;
Models for lifetime alcohol intake were stratified by center and age at recruitment. Systematic adjustment was undertaken for smoking intensity, physical activity level, educational attainment, diabetes status, BMI, height, duration of alcohol drinking, time since quitting, and an indicator variable for drinkers;
12g of alcohol correspond to about one standard glass of either wine, beer or spirits;
The category 0.1 to 4.9 g/days was used as the reference category;
Wald test for overall significance, according to the χ2 distribution with degrees of freedom equal to the number of categories minus one.