Table 4. Hazard Ratio¹ (95% CI) for overall pancreatic cancer risk by categories of baseline alcohol use (g/day) and smoking status (never and current smokers at baseline).

All participants	Never smokers				Current smokers
	Cases	PY	HR3	(95%CI)	Cases	PY	HR3	(95%CI)	pheterogeneity4
Continuous (12 g/day)2
	494	3,286,210	1.06	(0.98, 1.15)	422	1,469,414	1.05	(1.00, 1.11)
ptrend				0.13				0.04	0.84
Categories (g/day)
Non consumers	86	578,541	0.94	(0.71, 1.23)	51	176026.5	1.26	(0.89, 1.77)
0.1 - 4.9	182	1,261,449	1.00	(Ref)	105	439200.4	1.00	(Ref)
5 - 14.9	126	879,891	0.99	(0.79, 1.25)	88	360975.2	0.91	(0.68, 1.22)
15 - 29.9	60	359,073	1.08	(0.82, 1.50)	73	227177.8	1.19	(0.87, 1.63)
30 - 59.9	28	176,457	0.93	(0.65, 1.48)	71	193786.8	1.25	(0.91, 1.73)
≥ 60	12	30,799	2.17	(1.18, 3.99)	34	72247.58	1.50	(1.00, 2.28)
pWald5				0.14				0.10	0.41

¹Models were stratified by centre, age at recruitment and sex. Systematic adjustment was undertaken for smoking status, physical activity level, educational attainment, diabetes status, BMI, height, and an indicator variable for drinkers;

²12g of alcohol correspond to about one standard glass of either wine, beer or spirits/liquors;

³Models included interaction terms between baseline alcohol use and a smoking indicator (0=never smokers; 1=current smokers), keeping as reference category the group of light alcohol users (0.1–4.9 g/day) among never smokers, whereas former smokers and participants without information on their smoking status were excluded;

⁴Differences in HRs were assessed comparing the log-likelihood of models with and without interaction terms between alcohol and smoking status to one degree of freedom χ² distribution for analyses in continuous, and to five degrees of freedom χ² distribution for analyses in categories;

⁵P-value was determined using a Wald test for contrasts according to a χ² distribution with five degrees of freedom.