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. 2017 Jun 20;2017(6):CD007935. doi: 10.1002/14651858.CD007935.pub2

Summary of findings 4. Cognitive didactic therapy compared to functional experiential therapy for people with traumatic brain injury.

Cognitive didactic therapy compared to functional experiential therapy for people with traumatic brain injury
Patient or population: adult veterans or active duty military service personnel with moderate‐to‐severe traumatic brain injury
 Settings: acute inpatient rehabilitation brain injury programmes at 4 Veterans Administration medical centres, US
 Intervention: cognitive didactic therapy
 Comparison: functional experiential therapy
Outcomes Illustrative comparative risks* (95% CI) Relative effect
 (95% CI) No of participants
 (studies) Quality of the evidence
 (GRADE) Comments
Assumed risk Corresponding risk
Functional experiential therapy Cognitive didactic therapy
Return to work 
 Return to work status
 Follow‐up: 1 year (medium‐term) 354 per 1000 389 per 1000 
 (294 to 516) RR 1.10 
 (0.83 to 1.46) 366
 (1 study) ⊕⊕⊕⊝
 Moderate1
Independence in ADL 
 Structured interview
 Follow‐up: 1 year (medium‐term) 616 per 1000 554 per 1000 
 (462 to 665) RR 0.90 
 (0.75 to 1.08) 366
 (1 study) ⊕⊕⊝⊝
 Low2
*The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).
 A DL: activities of daily living; CI: confidence interval; RR: risk ratio.
GRADE Working Group grades of evidence
 High quality: Further research is very unlikely to change our confidence in the estimate of effect.
 Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate.
 Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate.
 Very low quality: We are very uncertain about the estimate.

1 Downgraded by 1 level because of imprecision. Confidence interval overlapped with both 1 and 1.25. The total number of events was fewer than 300.
 2 Downgraded by 2 levels because of imprecision. Confidence interval overlapped with both 0.75 and 1.25. The total number of events was fewer than 300.