Study	Outcomes	Efficacy
Romano 2009	Self reported VAS before and after 4 weeks of treatment	For participants with LANSS > 12 (n = 16): Celecoxib only Pre 47 mm Post 46 mm Pregbalin only Pre 47 mm Post 36 mm Combination Pre 48 mm Post 23 mm Pregabalin and combination, but not celecoxib alone, showed significant pain intensity reduction
Shackelford 2009	≥30 pain reduction ≥50% pain reduction PGIC much or very much improved Also mean pain changes	≥ 30% pain reduction Placebo ‐ 17/66 GW406381 25 ‐ 19/72 GW406381 50 ‐ 21/71 ≥ 30% pain reduction Placebo ‐ 4/66 GW406381 25 ‐ 10/72 GW406381 50 ‐ 12/71 PGIC responder Placebo ‐ 13/66 GW406381 25 ‐ 17/72 GW406381 50 ‐ 21/71
PGIC: Patient Global Impression of Change; VAS: visual analogue scale