Study	Reason for exclusion
Abbott 1968	Ineligible outcomes
Agren 1985	Ineligible outcomes
Ahmad 2008	Ineligible intervention
Alvarez 1999	Ineligible outcomes
Alvarez 2000a	Ineligible outcomes
Alvarez 2000b	Ineligible outcomes
Alvarez 2002	Ineligible outcomes
Alvarez Vázquez 2014	Ineligible patient population
Aminian 1999	Ineligible type of healing outcome
Amione 2005	Comparison of two interventions in the same class
Anitua 2008	Ineligible patient population
Anonymous 1982	Ineligible study design
Anonymous 2000	Ineligible study design
Anzai 1989	Ineligible patient population
Avanzi 1998a	Ineligible outcomes
Avanzi 1998b	Ineligible outcomes
Avanzi 2000a	Ineligible outcomes
Avanzi 2000b	Ineligible outcomes
Avanzi 2000c	Ineligible outcomes
Avanzi 2001	Ineligible outcomes
Baade 1965	Ineligible intervention
Baatenburg de Jong 2004	Ineligible patient population
Baker 1981	Ineligible study design
Bale 1997b	Ineligible outcomes
Bale 1997c	Comparison of two interventions in the same class
Bale 1998a	Ineligible patient population
Bale 1998b	Ineligible outcomes
Bale 2004	Ineligible outcomes
Banks 1997a	Ineligible outcomes
Banks 1997b	Ineligible indication
Barnes 1992	Comparison of two interventions in the same class
Bazzigaluppi 1991	Ineligible study design
Becker 1984	Ineligible type of healing outcome
Beele 2010	Ineligible patient population
Berard 1986	Ineligible study design
Bigolari 1991	Ineligible patient population
Bito 2012	Mixed intervention
Blanco Blanco 2002	Ineligible indication
Blum 1973	Ineligible patient population
Boxer 1969	Ineligible outcomes
Boykin 1989	Ineligible study design
Brady 1987	Ineligible study design
Brem 2000	Ineligible study design
Brett 2003	Ineligible outcomes
Brown‐Etris 1999a	Ineligible type of healing outcome
Brown‐Etris 1999b	Mixed intervention
Burgos 2000	Comparison of two interventions in the same class
Burke 1998	Ineligible type of healing outcome
Capillas Pérez 2000	Ineligible patient population
Carusone 2001	Ineligible indication
Casali 1997	Ineligible study design
Chang 1998	Ineligible outcomes
Chen 2004	Ineligible intervention
Cheneworth 1994	Ineligible study design
Chirwa 2010	Ineligible patient population
Chuangsuwanich 2011a	Ineligible type of healing outcome
Chuangsuwanich 2011b	Ineligible outcomes
Chuangsuwanich 2013	Ineligible outcomes
Colin 1996a	Ineligible type of healing outcome
Colin 1996b	Ineligible type of healing outcome
Colonna 2004	Ineligible study design
Cooper 2008	Ineligible patient population
Coutts 2000	Ineligible outcomes
D'Aniello 1998	Ineligible outcomes
Dat 2014	Ineligible study design
Day 1995	Comparison of two interventions in the same class
De Laat 2005	Ineligible outcomes
De Laat 2011	Ineligible type of healing outcome
Dealey 1997	Ineligible outcomes
Dealey 1998	Ineligible study design
Dealey 2008	Editorial
Dierick 2004a	Ineligible outcomes
Dierick 2004b	Ineligible type of healing outcome
Dobrzanski 1990	Comparison of two interventions in the same class
Durović 2008	Ineligible type of healing outcome
Dwivedi 2016	Ineligible type of healing outcome
El Zayat 1989	Ineligible study design
Ellis 2002	Ineligible type of healing outcome
Ellis 2003	Ineligible type of healing outcome
Engdahl 1980	Ineligible study design
Esch 1989	Ineligible type of healing outcome
Farsaei 2014	Ineligible patient population
Fear 1992	Ineligible outcomes
Feldman 2005	Ineligible type of healing outcome
Felzani 2011	Ineligible type of healing outcome
Flanagan 1995	Ineligible study design
Ford 2002	Mixed intervention
Fowler 1983	Ineligible study design
Franek 2011	Mixed intervention
Franek 2012	Mixed intervention
Franken 1999	Ineligible type of healing outcome
Fulco 2015	Ineligible type of healing outcome
Fønnebø 2008	Ineligible study design
García González 2002	Ineligible outcomes
Garrett 1969	Ineligible outcomes
Gerding 1992	Ineligible patient population
Gilligan 2014	Ineligible intervention
Goldmeier 1997	Ineligible type of healing outcome
Gostishchev 1983	Ineligible study design
Greer 1999	Ineligible type of healing outcome
Gregory 1997	Ineligible intervention
Guthrie 1989	Ineligible type of healing outcome
Hamilton Hislop 1962	Ineligible study design
Hampton 1998	Ineligible patient population
Harada 1996	Ineligible type of healing outcome
Harding 1996	Ineligible outcomes
Harding 2000	Ineligible study design
Helaly 1988	Ineligible patient population
Heuckeroth 2013	Ineligible study design
Heyer 2013	Ineligible study design
Hinz 1986	Ineligible patient population
Hirshberg 2001	Ineligible intervention
Hock 1997	Comparison of two interventions in the same class
Hofman 1994	Ineligible type of healing outcome
Horch 2005	Ineligible study design
Hsu 2000	Ineligible study design
Hu 2009	Ineligible patient population
Ishibashi 1991	Ineligible patient population
Ishibashi 1996	Ineligible patient population
Janssen 1989	Ineligible patient population
Jercinovic 1994	Ineligible intervention
Johnson 1992	Mixed intervention
Kallianinen 2000	Ineligible intervention
Karap 2008	Ineligible outcomes
Kerihuel 2010	Ineligible type of healing outcome
Kerstein 2004	Ineligible study design
Kim 1996	Ineligible patient population
Kloth 2000a	Mixed intervention
Kloth 2000b	Ineligible study design
Kloth 2001	Mixed intervention
Kloth 2002	Mixed intervention
Knudsen 1982	Ineligible type of healing outcome
Kohr 2000	Ineligible outcomes
Kordestani 2008	Ineligible study design
Kucan 1981	Ineligible outcomes
Kuflik 2001	Ineligible patient population
Kuisma 1987	Ineligible indication
Kukita 1990	Ineligible type of healing outcome
Kurring 1994	Ineligible study design
Kurzuk‐Howard 1985	Ineligible study design
Landi 2003	Ineligible intervention
Langer 1996	Ineligible intervention
Lazareth 2012	Ineligible patient population
Lechner 1991	No results
Lee 1975	Ineligible type of healing outcome
Lee 2014	Ineligible patient population
LeVasseur 1991	Ineligible study design
Li 2016	Dressings/topical agents not the only difference between interventions (nursing care was also different)
Lin 1997	Ineligible study design
Lindsay 2011	Ineligible study design
Lingner 1984	Ineligible study design
Liu 2012	Ineligible type of healing outcome
Liu 2013	Ineligible study design
Ljungberg 1998	Ineligible type of healing outcome
Llewellyn 1996	Ineligible outcomes
Lopez‐Jimenez 2003	Ineligible outcomes
Lum 1996	Ineligible type of healing outcome
Macario 2002	Ineligible study design
Manzanero‐Lopez 2004	Protocol only and review still not published
Martin 1996	Ineligible outcomes
Meaume 1996a	Ineligible type of healing outcome
Meaume 1996b	Ineligible type of healing outcome
Meaume 2005	Ineligible patient population
Mian 1992	Ineligible study design
Milne 2012	Confounded ‐ selection into phase 2 of trial on basis of results
Mizuhara 2012	Mixed intervention
Mo 2015	Ineligible patient population
Moberg 1983	Mixed intervention
Mody 2008	Ineligible type of healing outcome
Moody 1991	Ineligible study design
Moody 2002	Ineligible study design
Moore 2011	Ineligible patient population
Morimoto 2015	Ineligible study design
Motta 1991	Ineligible study design
Motta 2004	Ineligible patient population
Mouës 2004	Ineligible patient population
Mouës 2007	Ineligible patient population
Mulder 1989a	Ineligible patient population
Mulder 1989b	Ineligible patient population
Mulder 1993a	Ineligible type of healing outcome
Mulder 1993b	Ineligible type of healing outcome
Mustoe 1994	Ineligible intervention
Myers 1990	Ineligible type of healing outcome
Münter 2006	Ineligible patient population
Nasar 1982	Ineligible type of healing outcome
NCT02299557	Ineligible patient population
Neill 1989b	Ineligible study design
Niezgoda 2004	Ineligible type of healing outcome
Niimura 1990	Ineligible patient population
Niimura 1991	Ineligible patient population
Nixon 1998	Ineligible intervention
Ohura 2004	Mixed intervention
Olivar 1999	Ineligible intervention
Ovington 1999	Ineligible study design
Ozdemir 2011	Ineligible type of healing outcome
Panahi 2015	Ineligible patient population
Payne 2001	Ineligible intervention
Perez 2000	Ineligible type of healing outcome
Peschardt 1997	Ineligible type of healing outcome
Picard 2015	Ineligible patient population
Pierce 1994	Ineligible outcomes
Pullen 2002	Ineligible outcomes
Quelard 1985	Ineligible intervention
Ramsay 1979	Ineligible study design
Rhodes 1979	Ineligible study design
Rhodes 2001	Ineligible type of healing outcome
Roberts 1959	Ineligible indication
Robson 1992a	Ineligible type of healing outcome
Robson 1992b	Ineligible intervention
Robson 1992c	Ineligible intervention
Robson 1994	Ineligible intervention
Romanelli 2008	Ineligible patient population
Romanelli 2009	Ineligible patient population
Rooman 1991	Ineligible patient population
Routkovsky‐Norval 1996	Comparison of two interventions in the same class
Saha 2012	Ineligible type of healing outcome
Saidkhani 2016	Ineligible study design
Sayag 1996	Ineligible type of healing outcome
Saydak 1990	Ineligible study design
Scevola 2010	Ineligible outcomes
Scott 1999	Ineligible study design
Seaman 2000	Comparison of two interventions in the same class
Sebern 1989	Ineligible outcomes
Serra 2005	Ineligible study design
Settel 1969	Ineligible type of healing outcome
Shamimi Nouri 2008	Ineligible outcomes
Shannon 1988	Ineligible study design
Sherman 2000	Ineligible study design
Shirakawa 2005	Ineligible study design
Shojaei 2008	Ineligible outcomes
Shrivastava 2011	Ineligible patient population
Sibbald 2011	Ineligible patient population
Small 2002	Mixed intervention
Smietanka 1981	Ineligible study design
Souliotis 2016	Ineligible type of healing outcome
Stepan 2014	Ineligible study design
Stephen 2016	Ineligible type of healing outcome
Stoker 1990	Ineligible study design
Strong 1985	Ineligible type of healing outcome
Subbanna 2007	Ineligible type of healing outcome
Takahashi 2006	Ineligible study design
Teot 2008	Ineligible outcomes
Teot 1997	Ineligible type of healing outcome
Tewes 1993	Ineligible study design
Thomas 1993	Ineligible outcomes
Thomas 1997b	Ineligible outcomes
Toba 1997	Ineligible type of healing outcome
Tolentino 2011	Ineligible study design
Toriyabe 2004	Ineligible study design
Torra i Bou 1999	Ineligible outcomes
Trial 2010	Ineligible outcomes
Tricco 2015	Ineligible study design
Unglaub 2004	Ineligible type of healing outcome
Valentini 2015	Ineligible type of healing outcome
Van Leen 2004	Ineligible study design
Varma 1973	Ineligible outcomes
Vernassiere 2005	Ineligible patient population
Wagstaff 2014	Comparison of two interventions in the same class
Wallace 2009	Ineligible study design
Wang 2014	Ineligible intervention
Wanner 2003	Ineligible type of healing outcome
Watts 1994	Ineligible outcomes
Waycaster 2011	Ineligible type of healing outcome
Waycaster 2013	Confounded ‐ selection into phase 2 of trial on basis of results
Weheida 1991	Ineligible patient population
Weststrate 1999	Ineligible study design
Whitney 1999	Mixed intervention
Whitney 2001	Mixed intervention
Wild 2009	Ineligible outcomes
Wild 2012	Ineligible outcomes
Winter 1990	Ineligible patient population
Woo 2009	Ineligible outcomes
Worsley 1991	Ineligible patient population
Yastrub 2004	Ineligible type of healing outcome
Yastrub 2005	Ineligible type of healing outcome
Young 1973	Ineligible study design
Young 1997	Ineligible type of healing outcome
Yura 1984	Ineligible patient population
Zhou 2001	Ineligible intervention
Zuloff‐Shani 2010	Ineligible study design