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. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: Expert Rev Mol Diagn. 2018 Jul 13;18(8):701–712. doi: 10.1080/14737159.2018.1495076

Figure 2.

Figure 2.

Left panel: experimental DMF cartridge for performing enzymatic assays by fluorometry. There are 12 sample inputs (right edge), 8 reagent inputs (top and bottom edge) plus additional reservoirs for stop buffer and waste. Individual droplets are dispensed, mixed and manipulated entirely by software. Right panel: results of enzymatic assays for the enzymes deficient in Fabry (GLA) disease and Pompe (GAA) disease by DMF using a 1 h incubation time. Results for known affected patients (GLA: n=6; GAA: n=7) are compared with presumed unaffected controls (n=105) and show no overlap. Data modified and reprinted with permission from the American Association of Clinical Chemistry [12].