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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: DNA Repair (Amst). 2019 Feb 27;77:36–44. doi: 10.1016/j.dnarep.2019.02.014

Figure 2. Repair of uracil in DNA. Left: uracil in DNA is excised primarily by base excision repair.

Figure 2.

One of several uracil DNA glycosylases excise uracil, leaving an AP site. APE1 recognizes these sites and creates single strand breaks. POL β fills in these sites, and LIG3 seals the nick. Right: Mismatch repair can excise repair uracil from DNA. Uracil is recognized by the MSH2-MSH6 heterodimer. The MLH1-PMS3 heterodimer creates nick on either side of the uracil moiety. EXO1 degrades the nicked DNA. DNA is filled in by either POL δ or POL ε. BER = base excision repair. U, Uracil; UDG, uracil DNA glycosylase;.AP, abasicsite; APE1, AP endonuclease 1; POL β, DNA pol beta; MSH2, MutS homolog 2; MSH6, MutS homolog 6; MLH1, MutL homolog 1; PMS2, PMS1 homolog 2; EXO1, Exonuclease 1; Pol δ, DNA polymerase δ; Pol ε, DNA polymerase ε.