Figure 4.

PCB 126 treatment differentially modulates fermentative SCFA from moderate concentrations of the dietary fiber inulin. Bacterial cell suspensions were maintained on inulin substrate (4 g/L) and subsequently exposed to PCB 126 (0.02 μM, 0.2 μM, 2 μM) or vehicle control (DMSO) for 48h (n=3). HPLC was utilized to quantify fermentation acids in the media after incubation. PCB 126 significantly reduced production of succinate at 0.2 μM and 2μM exposure concentrations and significantly increased propionate production at the 2 μM concentration. All data are presented as means ± SEM. * Significantly different compared to vehicle control (DMSO) (p<0.05; Student’s t-test).