TABLE II.

Comparison of prevalent animal species used as in vivo wound healing models.

Model	Advantages	Disadvantages
Rodent	• Strong understanding of genetic makeup	• Skin characteristics present differences in the healing mechanism
	• Multiple specialized models available	• Differences in hair growth
	• Chronic healing models available	• High physical activity of animal can impact wound healing environment
	• Relatively low cost to house and maintain	• Irrelevant wound size
	• Simple surgical operations
Pig	• Skin is similar to humans	• Lack of specialized models
	• Comparable healing characteristics to humans	• Ethical considerations
	• Generation of wounds at relevant scales	• Complex surgical operations
		• High cost to house and maintain
		• Need for specialized facilities