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. 2018 Dec 26;2(4):046107. doi: 10.1063/1.5052239

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© 2018 Author(s).

2473-2877/2018/2(4)/046107/16

All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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FIG. 4. — ECM alignment influences migration speed independent of ECM density. (a) Overlaid outlines of representative cells at the end of each hour (as denoted by color bar) over 6 h time-lapse imaging on non-aligned (NA, ±90°) and aligned (AL, ±5°) Fn-patterns (grey) containing 100 lines with a width of 1 μm. (b) 20 representative cell migration tracks measured over 6 h duration of time-lapse imaging on NA and AL patterns containing 100 lines with a width of 1 μm. Average migration speeds (c) and persistence (d) on NA and AL patterns containing 50, 100, 200, or 400 lines (n ≥ 10 cells per condition, ≥160 cells analyzed total, * indicates a significant difference with p < 0.05 vs. NA group at the same line density). Scale bars: 100 μm.