Percent with outcome
Reference	Topical treatment	Studies/participants	Active	Placebo	RR 95% CI	NNT 95% CI	Susceptibility to publication bias	GRADE (review‐reported)
Acute pain conditions
Derry 2015	Diclofenac ‐ Flector plaster	4/1030	63	41	1.5 (1.4 to 1.7)	4.7 (3.7 to 6.5)	5029	No specific GRADE given
Derry 2015	Diclofenac ‐ Emulgel	2/314	78	20	3.8 (2.7 to 5.5)	1.8 (1.5 to 2.1)	1430	High quality
Derry 2015	Ketoprofen ‐ gel	5/348	72	33	2.2 (1.7 to 2.8)	2.5 (2.0 to 3.4)	1044	Moderate quality
Derry 2015	Diclofenac ‐ other plaster	3/474	88	57	1.6 (1.4 to 1.8)	3.2 (2.6 to 4.2)	1007	No specific GRADE given
Derry 2015	Piroxicam gel	3/522	70	47	1.5 (1.3 to 1.7)	4.4 (3.2 to 6.9)	664	No specific GRADE given
Chronic pain conditions
Derry 2016	Ketoprofen gel	4/2573	63	48	1.1 (1.01 to 1.2)	6.9 (5.4 to 9.3)	1156	Moderate quality
Derry 2016	Diclofenac (< 6 weeks' duration)	5/732	43	23	1.9 (1.5 to 2.3)	5.0 (3.7 to 7.4)	732	Moderate quality
Derry 2016	Diclofenac ‐ various formulations (> 6 weeks' duration)	4/2343	60	50	1.2 (1.1 to 1.3)	9.8 (7.1 to 16)	48	Moderate quality
Derry 2017	Capsaicin (high‐concentration)	2/571	33	24	1.3 (1.0 to 1.7)	11 (6.1 to 62)	Result above threshold of 10	Moderate quality