Percent with outcome
Reference	Condition treated	Topical treatment	Studies/Participants	Active	Placebo	RR 95% CI	NNH 95% CI	GRADE (review‐reported)
Acute pain conditions
Pattanittum 2013	Lateral elbow pain	Diclofenac	3/153	2	1	1.6 (0.2 to 12)	n/c	Low quality
Derry 2015 (Systemic adverse events)	Strains and sprains	All NSAIDs	36/5576	3	4	1.0 (0.7 to 1.3)	n/c	High quality
Chronic pain conditions							NNH
Wrzosek 2015	Neuropathic pain	Clonidine	2/344	12	13	0.7 (0.1 to 3.1)	n/c	Very low quality
Derry 2016 (Systemic adverse events)	Knee and hand OA	Diclofenac	7/1266	6	7	0.9 (0.6 to 1.3)	n/c	Very low quality
Acute and chronic pain conditions							NNH
Derry 2014b	OA or LBP	Salicylate	11/984	15	9	1.6 (1.2 to 2.0)	17 (9.9 to 58)	Low quality