Comparison 1. Alvimopan versus placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Time‐to‐tolerance of a solid diet AND documented bowel movements	1	280	Hazard Ratio (Random, 95% CI)	1.77 [1.41, 2.23]
2 Time‐to‐hospital discharge	1	238	Hazard Ratio (Random, 95% CI)	1.67 [1.38, 2.01]
3 Major adverse events	1	277	Risk Ratio (M‐H, Random, 95% CI)	0.28 [0.18, 0.44]
4 Nasogastric tube (re‐)placement within 30 postoperative days	1	277	Risk Ratio (M‐H, Random, 95% CI)	0.31 [0.16, 0.59]
5 Readmission	1	277	Risk Ratio (M‐H, Random, 95% CI)	0.89 [0.59, 1.33]
6 Narcotic pain medication use	1	277	Mean Difference (IV, Random, 95% CI)	0.0 [‐14.08, 14.08]
7 Any cardiovascular event	1	277	Risk Ratio (M‐H, Random, 95% CI)	0.54 [0.27, 1.05]