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. 2017 May 24;2017(5):CD005070. doi: 10.1002/14651858.CD005070.pub3

Abdelmassih 2006.

Methods Prospective randomised study, single centre.
Randomisation method: not stated.
Power analysis: not stated.
Study period: not stated.
Sample size: 206 women.
Conflict of interest: not stated.
Participants Normagonadotropic women with an indication for IVF/ICSI.
Age < 35 years.
No available baseline characteristics to compare.
Interventions Luteal started pituitary downregulation with GnRH agonist.
Standard treatment: from cycle day 2 onward daily 225 IU/L rFSH subcutaneous.
Experimental treatment: from cycle day 7 onward daily additional 75 IU/L rLH until ovulation triggering with hCG.
Outcomes Primary endpoints:
  • clinical pregnancy rate, not defined

  • implantation rate, not defined

  • miscarriage rate, not defined


Secondary endpoint:
  • embryo quality, not defined

Notes Abstract only.
Funding: not stated
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Method of randomization not stated.
Allocation concealment (selection bias) Unclear risk Method of allocation concealment not stated.
Blinding of participants and personnel (performance bias) 
 All outcomes Low risk Non‐blinding not likely to affect the outcomes of interest as they are objectively assessed.
Blinding of outcome assessment (detection bias) 
 All outcomes Low risk Those who administered the intervention were not blinded but non‐blinding of outcome assessment not likely to affect the outcomes of interest as they are objectively assessed.
Incomplete outcome data (attrition bias) 
 All outcomes Unclear risk Only abstract available.
Selective reporting (reporting bias) Unclear risk Study protocol not available, no live birth rates.
Other bias Unclear risk Insufficient information to make a conclusive judgement.