Barrenetxea 2008.

Methods	Prospective randomized study, single centre. Randomisation: computer‐generated block randomization. Allocation: sealed envelopes. Power analyses: 10% difference in clinical pregnancy rate. Sample size: 84. Study period: January to June 2005. Conflict of interest: not stated.
Participants	Women with an indication for IVF and poor ovarian reserve. Age > 40 year. FSH cycle day 3 > 10. Available baseline characteristics to compare: mean age, BMI, duration of infertility, basal FSH.
Interventions	Follicular started pituitary downregulation with a GnRH agonist 0.5 mg/day leuprolide. Standard treatment: from cycle day 2 onward 375 rFSH. Experimental treatment from stimulation day 7 until stimulation day 10 150 IU rLH, from stimulation day 10 onward daily additional 75 IU rLH until ovulation triggering with hCG.
Outcomes	Primary endpoints: ongoing pregnancy rate, defined as heart activity at 12 weeks gestation Secondary endpoints: cancellation rate, implantation rates, days of ovarian stimulation, number of total retrieved oocytes and fertilisation rates
Notes	No data on live births. Funding: not stated
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	'Computer‐generated' block randomization.
Allocation concealment (selection bias)	Low risk	Allocations were concealed in 'sealed envelopes'.
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Non‐blinding is not likely to affect the outcomes of interest as they are objectively assessed.
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Those who administered the intervention were not blinded but non blinding of outcome assessment is not likely to affect the outcomes of interest as they are objectively assessed.
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Insufficient information to make a conclusive judgement.
Selective reporting (reporting bias)	Unclear risk	No data on live births.
Other bias	Low risk	Baseline demographic characteristics similar between groups.