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. 2017 May 24;2017(5):CD005070. doi: 10.1002/14651858.CD005070.pub3

Berkkanoglu 2007.

Methods Prospective randomized study, single centre.
Randomisation method: not stated.
Power analyses: not stated.
Sample size: 97.
Study period: not stated.
Conflict of interests: not stated.
Participants Women undergoing ICSI, indication not stated, only first treatment cycle having more than 3 follicles on stimulation day 7.
Aged < 42
AFC < 12
FSH < 12
Baseline characteristics to compare: age, AFC, basal FSH.
Interventions Follicular started flare‐up GnRH agonist microdose 40 mg (twice daily) pre‐treated with OC.
Standard treatment: from cycle day 3 onward 600 IU rFSH.
Experimental treatment: from cycle day 3 onward daily additional 75 IU rLH until ovulation triggering with rhCG.
Outcomes Primary outcome: not stated.
Clinical effects: not defined.
Notes No data on live births.
Funding: not stated
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Method of randomization not stated.
Allocation concealment (selection bias) Unclear risk Method of concealment not stated.
Blinding of participants and personnel (performance bias) 
 All outcomes Low risk Non‐blinding is not likely to affect the outcomes of interest as they are objectively assessed.
Blinding of outcome assessment (detection bias) 
 All outcomes Low risk Those who administered the intervention were not blinded but non‐blinding of outcome assessment is not likely to affect the outcomes of interest as they are objectively assessed.
Incomplete outcome data (attrition bias) 
 All outcomes Unclear risk No study protocol available.
Selective reporting (reporting bias) Unclear risk No data on live births.
Other bias Unclear risk Insufficient information to make a conclusive judgement.