Berkkanoglu 2007.
Methods | Prospective randomized study, single centre. Randomisation method: not stated. Power analyses: not stated. Sample size: 97. Study period: not stated. Conflict of interests: not stated. |
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Participants | Women undergoing ICSI, indication not stated, only first treatment cycle having more than 3 follicles on stimulation day 7. Aged < 42 AFC < 12 FSH < 12 Baseline characteristics to compare: age, AFC, basal FSH. |
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Interventions | Follicular started flare‐up GnRH agonist microdose 40 mg (twice daily) pre‐treated with OC. Standard treatment: from cycle day 3 onward 600 IU rFSH. Experimental treatment: from cycle day 3 onward daily additional 75 IU rLH until ovulation triggering with rhCG. |
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Outcomes | Primary outcome: not stated. Clinical effects: not defined. |
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Notes | No data on live births. Funding: not stated |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Method of randomization not stated. |
Allocation concealment (selection bias) | Unclear risk | Method of concealment not stated. |
Blinding of participants and personnel (performance bias) All outcomes | Low risk | Non‐blinding is not likely to affect the outcomes of interest as they are objectively assessed. |
Blinding of outcome assessment (detection bias) All outcomes | Low risk | Those who administered the intervention were not blinded but non‐blinding of outcome assessment is not likely to affect the outcomes of interest as they are objectively assessed. |
Incomplete outcome data (attrition bias) All outcomes | Unclear risk | No study protocol available. |
Selective reporting (reporting bias) | Unclear risk | No data on live births. |
Other bias | Unclear risk | Insufficient information to make a conclusive judgement. |