Demirol 2005.
Methods | Prospective, randomized study, single centre. Randomisation method: not stated. Power analysis: not stated. Study period: not stated. Sample size: 106 patients. Conflict of interests: not stated. |
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Participants | Women with previous failed IVF cycle due to poor response (number of oocytes < 3 maximal E2 < 500 pg/ml). Age: not stated. FSH: not stated. Exclusion criteria: not stated. Baseline characteristics to compare: age, BMI, FSH, type of infertility. |
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Interventions | Short GnRH antagonist cetrorelix protocol. On cycle day 2 450 IU rFSH alone was started in a step‐down protocol with 150 IU rLH and on stimulation day 6 cetrorelix until ovulation triggering with HCG. | |
Outcomes | Primary outcome: not stated. Secondary outcome: cancellation rate (defined), duration of stimulation, number of follicles and oocytes, fertilisation rate, implantation rate (not defined) and pregnancy rate (not defined). |
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Notes | Abstract only. Funding: not stated |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | No information on random sequence generation. |
Allocation concealment (selection bias) | Unclear risk | No information on allocation concealment. |
Blinding of participants and personnel (performance bias) All outcomes | Low risk | Non‐blinding is not likely to affect the outcomes of interest as they are objectively assessed. |
Blinding of outcome assessment (detection bias) All outcomes | Low risk | No information was provided on whether or not outcome assessors were blinded but non‐blinding of outcome assessment is not likely to affect outcomes of interest as they are objectively assessed. |
Incomplete outcome data (attrition bias) All outcomes | Unclear risk | insufficient information to make a conclusive judgement. |
Selective reporting (reporting bias) | Low risk | Outcome measures were prespecified in the methods section. |
Other bias | Unclear risk | Insufficient information to make a conclusive judgement. |