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. 2017 May 24;2017(5):CD005070. doi: 10.1002/14651858.CD005070.pub3

Demirol 2005.

Methods Prospective, randomized study, single centre.
Randomisation method: not stated.
Power analysis: not stated.
Study period: not stated.
Sample size: 106 patients.
Conflict of interests: not stated.
Participants Women with previous failed IVF cycle due to poor response (number of oocytes < 3 maximal E2 < 500 pg/ml).
Age: not stated.
FSH: not stated.
Exclusion criteria: not stated.
Baseline characteristics to compare: age, BMI, FSH, type of infertility.
Interventions Short GnRH antagonist cetrorelix protocol. On cycle day 2 450 IU rFSH alone was started in a step‐down protocol with 150 IU rLH and on stimulation day 6 cetrorelix until ovulation triggering with HCG.
Outcomes Primary outcome: not stated.
Secondary outcome: cancellation rate (defined), duration of stimulation, number of follicles and oocytes, fertilisation rate, implantation rate (not defined) and pregnancy rate (not defined).
Notes Abstract only.
Funding: not stated
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk No information on random sequence generation.
Allocation concealment (selection bias) Unclear risk No information on allocation concealment.
Blinding of participants and personnel (performance bias) 
 All outcomes Low risk Non‐blinding is not likely to affect the outcomes of interest as they are objectively assessed.
Blinding of outcome assessment (detection bias) 
 All outcomes Low risk No information was provided on whether or not outcome assessors were blinded but non‐blinding of outcome assessment is not likely to affect outcomes of interest as they are objectively assessed.
Incomplete outcome data (attrition bias) 
 All outcomes Unclear risk insufficient information to make a conclusive judgement.
Selective reporting (reporting bias) Low risk Outcome measures were prespecified in the methods section.
Other bias Unclear risk Insufficient information to make a conclusive judgement.