Nazzaro 2012.

Methods	Randomised controlled trial. Randomisation method: not stated. Power analysis: not stated. Study period: not stated. Sample size: 422 patients. Conflict of interests: not stated.
Participants	Women without ovulatory dysfunction at their first IVF/ICSI cycle. Age: 35‐42 years. FSH: not stated. AFC: maximum 3 per ovary. Exclusion criteria: not stated. Baseline characteristics to compare: not stated.
Interventions	Pituitary downregulation with GnRH‐a starting on day two of the menstrual cycle. Standard treatment: rFSH administration (225 IU/day). Experimental treatment: rFSH (225 IU/day) + rLH (rLH 150 IU/day).
Outcomes	Primary endpoint: not stated. Endpoints: number of (MFII) oocytes, fertilisation rate, mean high grade embryos, mean number of frozen embryos, implantation rate (fresh+thawed embryos) and clinical pregnancy rate.
Notes	Abstract only. Funding: not stated
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	No information was reported on random sequence generation.
Allocation concealment (selection bias)	Unclear risk	No information was reported on allocation concealment.
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Non‐blinding is not likely to affect the outcomes of interest as they are objectively assessed.
Blinding of outcome assessment (detection bias) All outcomes	Low risk	No information was provided on the blinding of outcome assessors but non‐blinding of outcome assessment is not likely to affect outcomes of interest as they are objectively assessed.
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	No information was reported on withdrawals/dropouts and methods used in data analysis.
Selective reporting (reporting bias)	Unclear risk	Methods section not detailed enough to make a definite judgement on selective outcome reporting.
Other bias	Unclear risk	Insufficient information to make a conclusive judgement.