Pezzuto 2010.

Methods	Prospective randomized study. Randomisation:computer‐generated randomization list. Power analysis: not stated. Study period: March 2004 to October 2007. Sample size: 80. Conflict of interests: No conflicts of interest.
Participants	Healty woman undergoing IVF, with a regular mens. cycle and a normal uterine cavity after hysteroscopy. Age: between 20 and 39 years. FSH: < 10 IU/L. Exclusion criteria: not stated. Baseline characteristics to compare: mean age, BMI, baseline serum FSH, baseline serum LH, number of tubal factors, male factors, unexplained factors and endometriosis.
Interventions	Long GnRH agonist protocol. Standard treatment: 14 days after downregulation with leuprorelin, ovarian stimulation was initiated only with rFSH 225 IU. Experimental treatment: at the same time stimulation was initiated with rFSH 225 IU associated with rLH 75 IU on cycle day 6 of stimulation.
Outcomes	Primary endpoint: oocytes quality, classified into four maturation stages depending on the maturity of the oocyte‐cumulus‐corona complex. Secondary endpoints: duration of stimulation, FSH dose, serum E2 levels, follicular fluid VEGF levels, fertilisation rate, pregnancy rate.
Notes	Funding: not stated, but the authors declare that they are alone responsible for the content and writing of the paper.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Computer‐generated randomization list.
Allocation concealment (selection bias)	Unclear risk	Not stated.
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Non‐blinding is not likely to affect the outcomes of interest as they are objectively assessed.
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Non‐blinding of outcome assessors is not likely to affect the outcomes of interest as they are objectively assessed.
Incomplete outcome data (attrition bias) All outcomes	High risk	The reported outcomes were not specified in the methods section.
Selective reporting (reporting bias)	Low risk	No dropouts.
Other bias	Low risk	Baseline characteristics similar between the two treatment groups.