Van der Houwen 2011.

Methods	Prospective randomized multicentre study. Randomisation method: Not stated. Power analysis: Not stated. Study period: Not stated. Sample size: A total of 249 patients. Conflicts of interest: Not stated
Participants	Women who were undergoing IVF or ICSI. Age: 35 years or older. FSH: not stated. AFC: not stated. Exclusion criteria: not stated. Baseline characteristics to compare: not specified.
Interventions	Short pituitary downregulation protocol with GnRH antagonist with 225 IU rFSH started on cd 3. Standard treatment: rFSH alone. Experimental treatment: rFSH and rLH (Luveris 150 IU/day).
Outcomes	Primary endpoint: Not stated. Endpoints: Implantation rate (the chance of an individual embryo to implant), clinical pregnancy rate (defined as hCG > 50 IU) and ongoing pregnancy rate (defined as a pregnancy diagnosed by ultrasonographic visualisation with at least one foetus of 12 or more weeks of gestational age).
Notes	Abstract only. Funding: not stated
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	No information was reported on random sequence generation.
Allocation concealment (selection bias)	Unclear risk	No information was reported on allocation concealment.
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Non‐blinding is not likely to affect the outcomes of interest as they are objectively assessed.
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Non‐blinding of outcome assessment is not likely to affect outcomes of interest as they are objectively assessed.
Incomplete outcome data (attrition bias) All outcomes	Low risk	It was stated that data analysis was on ITT basis.
Selective reporting (reporting bias)	Low risk	All the outcomes reported were prespecified in the methods section.
Other bias	Unclear risk	No sufficient information was reported to make a conclusive judgement.