ChiCTR1800017313.

Study name	Clinical application of high‐flow nasal cannula therapy in patients with post‐traumatic ARDS
Methods	Randomized controlled trial. Stratified randomization based on the oxygenation index PaO2/FiO2 divided to three patients groups, and randomly assigned to two treatment arms
Participants	Estimated number of participants: 90 Setting: China Inclusion criteria: Group 1: < 24h of trauma; PO2/FiO2 = 200‐300 mmHg Group 2: < 24h of trauma; PO2/FiO2 = 200‐300 mmHg Group 3: trauma; intubated; pass SBT Exclusion criteria: Group 1: age < 18; informed consent not obtained; other organ failure; tracheotomy. Group 2: age < 18; informed consent not obtained; other organ failure; tracheotomy; severe ARDS requiring immediate intubation; NIV taboos. Group 3: age < 18; informed consent not obtained; NIV taboos; tracheotomy
Interventions	Intervention group (HFNC) Control group (NIV)
Outcomes	All outcomes measured: arterial blood gas; respiratory rate; blood pressure; change and time of respiratory support; whether invasive ventilation (endotracheal intubation) is required and time; dyspnoea score; comfort score; facial skin breakage; respiratory and extrapulmonary complications; length of stay in ICU; length of stay in hospital; discharge (death, healed/improved) Outcomes relevant to this review: arterial blood gas; respiratory rate; whether invasive ventilation (endotracheal intubation) is required and time; dyspnoea score; comfort score; respiratory and extrapulmonary complications; length of stay in ICU; length of stay in hospital; discharge (death, healed/improved)
Starting date	24 July 2017
Contact information	Li Yujie, 34504287@qq.com
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