NCT02290548.

Study name	Effect of high‐flow nasal oxygen vs standard oxygen therapy on extubation outcome with high risk of extubation failure in medical ICU patient
Methods	RCT, parallel‐group design
Participants	Estimated number of participants: 400 Setting: ICU, Taiwan Inclusion criteria: MV > 48 hrs; age > 65 years; cardiac failure primary indication for MV; COPD; bronchiectasis; old pulmonary tuberculosis with lung destruction; chronic renal failure; neuromuscular disease; BMI > 30 kg/m2; inability to manage respiratory secretions; ARDS Exclusion criteria: tracheostomy; recent facial trauma; active gastrointestinal bleeding; planned NIV support post‐extubation
Interventions	Intervention group (HFNC): Control group (standard oxygen therapy): nasal cannula or mask
Outcomes	All outcomes measured: reintubation rate; need for NIV; ICU readmission due to respiratory failure; ICU mortality; ICU length of stay; hospital mortality; hospital length of stay; hospital‐acquired pneumonia; desaturation to SpO2 < 90 %; severe hypoxaemia PaO2/FiO2 < 200; hypercapnia PaCO2 > 50; arterial pH < 7.30; severe tachypnoea (respiratory rate > 40 breaths/min) Outcomes relevant to this review: reintubation rate; need for NIV; ICU length of stay; hospital mortality; hospital length of stay; hospital‐acquired pneumonia
Starting date	14 November 2014
Contact information	Kuo Li Kuo, lmn4093@gmail.com
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