NCT03014869.

Study name	Comparison of high‐flow nasal cannula and non‐invasive positive ventilation (NPPV) in moderate chronic obstructive pulmonary disease exacerbation (AECOPD)
Methods	RCT, parallel‐group design
Participants	Estimated number of participants: 351 Setting: China Inclusion criteria: AECOPD; 7.35 > pH ≥ 7.25，PaCO2 > 50 mmHg Exclusion criteria: contraindications for NPPV, such as thick sputum, cough weakness, haemodynamic instability, etc.; need to be intubated immediately; refuse to engage in the study; severe organ dysfunction
Interventions	Intervention group (HFNC): flow = 25 to 60 L/min. FiO2 titrated to target SpO2 of 90 to 95%. Control group (NPPV)
Outcomes	All outcomes measured: intubation demand within 90 days; intubation rate within 90 days. Outcomes relevant to this review: intubation rate within 90 days
Starting date	9 January 2020
Contact information	Jingen Xia, xiajingen_00632@163.com
Notes