NCT03229460.

Study name	High‐flow nasal oxygen therapy in perioperative period of the adult with hypercapnic and hypoxemic respiratory failure
Methods	RCT, parallel‐group design
Participants	Estimated number of participants: 150 Setting: China Inclusion criteria: AHRF; severe dyspnoea at rest with respiratory rate > 25 breaths/min; PaO2/FiO2 < 300; PaCO2 < 45 mmHg Exclusion criteria: age < 18 years; contraindications to NIV; chronic respiratory disease; cardiac pulmonary oedema; predefined intubation; haemodynamic instability or need for vasopressors; GCS ≤ 12; profound leukopenia
Interventions	Intervention group (HFNC): flow = 30 to 60 L/min; FiO2 adjusted to target SpO2 > 92 % Control group 1 (standard oxygen therapy): flow ≥ 10 L/min Control group 2 (NIV): face mask; FiO2 and/or PEEP adjusted to target SpO2 > 92 %
Outcomes	All outcomes reported: intubation rate Outcomes relevant to this review: intubation rate
Starting date	25 July 2017
Contact information	Bin He, hebinicu@139.com. Dongjuan Tang, 317582862@qq.com
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