NCT03877172.

Study name	High‐flow nasal cannula in thoracic surgery: a physiologic study
Methods	RCT, cross‐over design. Single‐centre study. Randomized to intervention or control for 30 minutes
Participants	Estimated number of patients: 40 Setting: postoperative ICU, Spain Inclusion criteria: lung resection with expected MV > 180 mins Exclusion criteria: refusal to participate; contraindications to NG tube placement; age < 18; pregnancy; neuromuscular disease; prior thoracic surgery
Interventions	Intervention group (HFNC): Airvo 2, Fisher & Paykel; flow = 50 L/min Control group (standard oxygen therapy): conventional face mask FiO2 titrated to SpO2 > 92% for both groups
Outcomes	All outcomes reported: respiratory drive; thickening fraction of the right hemidiaphragm; diaphragmatic excursion; PaO2/FiO2; PaCO2; dyspnoea Outcomes relevant to this review: PaO2/FiO2; PaCO2; dyspnoea
Starting date	15 March 2019
Contact information	Ricard Mellado Artigas, rmartigas@gmail.com
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