NCT03928535.

Study name	Effect of post‐extubation high‐flow nasal cannula vs noninvasive ventilation on reintubation and post‐extubation respiratory failure in patients with hypercapnic COPD, a randomized controlled trial
Methods	RCT, parallel‐group design
Participants	Estimated number of participants: 100 Setting: respiratory ICU, China Inclusion Criteria: clinical diagnosis of AECOPD; > 48 hrs MV; HFNC or NIV immediately after extubation; PaCO2 ≥ 50 mmHg at point of extubation; PEEP ≤ 8 cm H2O at extubation Exclusion Criteria: do‐not‐intubate; tracheostomies; accidental extubation; self‐extubation
Interventions	Intervention group (HFNC): flow initially 10 L/min and titrated up in 5 L/min steps until intolerable; FiO2 was titrated to target SpO2 > 92% Control group (NIV): BiPAP for 24 hours then oxygen via Venturi mask. PEEP, IPAP and FiO2 were adjusted to achieve respiratory rate < 25 breaths/min and SpO2 > 92%
Outcomes	All outcomes measured: rate of reintubation within 72 hours; ICU length of stay; 28‐day mortality; PaCO2 Outcomes relevant to this review: rate of reintubation; ICU length of stay; 28‐day mortality; PaCO2
Starting date	26th April 2019
Contact information	Not available
Notes	Not yet recruiting