NCT04156139.

Study name	High‐flow nasal cannula versus noninvasive positive pressure ventilation therapy after early extubation for patients with chronic obstructive pulmonary disease
Methods	RCT, parallel‐group design
Participants	Estimated number of participants: 502 Setting: ICU, China Inclusion Criteria: age = 40 to 85 years; COPD patients with bronchopulmonary infection; patients with hypercapnic respiratory failure treated with invasive mechanical ventilation for between 48 hours and 14 days; reached the pulmonary infection control window; have self‐care ability with oxygen supply during stable phase Exclusion Criteria: severe organ dysfunction; myopathy or myasthenia gravis; upper airway obstruction; a large amount of secretions and inability to drain
Interventions	Intervention group (HFNC): flow rate = 45 to 55 L/min; FiO2 adjusted to maintain SpO2 ≥ 92% Control group (NIV): BiPAP; initial PEEP = 5 cm H2O; IPAP = 10 cm H2O; adjusted to target tidal volume of 6‐8 mL/kg
Outcomes	All outcomes measured: reintubation within 7 days; weaning failure within 7 days (composite criterion including reintubation and all‐cause mortality) Outcomes relevant to this review: reintubation, all‐cause mortality
Starting date	7th November 2019
Contact information	Han Xiaobo, hansir510@163.com
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