Table 2. Top gene ontology enrichment results for pfc mega module cadetblue.

Category	Name	p-value	q-value Bonferroni	Hit Count in Query List	Hit Count in Genome	Hit in Query List
GO: Biological Process	chromatin organization	1.50E-09	4.12E-06	23	776	SMYD1, ESR1, KAT6A, ASH1L, PAGR1, CBX4, KDM6B, ASH2L, MYSM1, PHF21A, BPTF, UBN1, CBX6, SUPT16H, SMARCD3, H3F3B, PAX5, PAX7, BRD1, CABIN1, MGEA5, NR1H4, CBX8
	histone modification	1.97E-06	5.40E-03	14	453	SMYD1, KAT6A, ASH1L, PAGR1, KDM6B, ASH2L, MYSM1, PHF21A, PAX5, PAX7, BRD1, MGEA5, NR1H4, CBX8
	covalent chromatin modification	2.87E-06	7.89E-03	14	468	SMYD1, KAT6A, ASH1L, PAGR1, KDM6B, ASH2L, MYSM1, PHF21A, PAX5, PAX7, BRD1, MGEA5, NR1H4, CBX8
	chromatin remodeling	1.47E-05	4.04E-02	8	165	SMYD1, ESR1, ASH2L, MYSM1, BPTF, SMARCD3, H3F3B, PAX7
	RNA splicing	1.60E-05	4.40E-02	12	403	SRSF6, NUDT21, BCAS2, RBM39, RALY, RBM5, PRPF19, AKT2, CPSF2, SNRPD3, WDR77, AQR
	protein alkylation	2.44E-05	6.71E-02	8	177	SMYD1, ASH1L, ASH2L, PAX5, PAX7, SNRPD3, WDR77, NR1H4
	protein methylation	2.44E-05	6.71E-02	8	177	SMYD1, ASH1L, ASH2L, PAX5, PAX7, SNRPD3, WDR77, NR1H4
GO: Cellular Component	nucleoplasm part	2.23E-05	7.49E-03	16	738	MMS22L, SRSF6, NUDT21, KAT6A, PAGR1, CBX4, ELMSAN1, ASH2L, RBM39, PHF21A, UBN1, TONSL, PRPF19, SPOP, CPSF2, BRD1
	chromosome	1.21E-04	4.07E-02	17	943	MMS22L, PSEN2, BCAS2, ESR1, KAT6A, ASH1L, ZNF207, ASH2L, ESCO2, CBX6, TONSL, SUPT16H, PRPF19, SMARCD3, H3F3B, NR1H4, CBX8
	ribonucleoside-diphosphate reductase complex	1.24E-04	4.17E-02	2	3	RRM2B, RRM2
	DNA replication factor A complex	1.39E-04	4.67E-02	3	16	BCAS2, TONSL, PRPF19
	nuclear replication fork	1.40E-04	4.71E-02	4	41	MMS22L, BCAS2, TONSL, PRPF19
	catalytic step 2 spliceosome	2.96E-04	9.94E-02	5	90	BCAS2, RALY, PRPF19, SNRPD3, AQR
GO: Molecular Function	oxidoreductase activity, acting on CH or CH2 groups	3.32E-05	1.62E-02	3	10	CYP2C8, RRM2B, RRM2
	oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor	1.31E-04	6.38E-02	2	3	RRM2B, RRM2
	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	1.31E-04	6.38E-02	2	3	RRM2B, RRM2
	ribonucleoside-diphosphate reductase activity	1.31E-04	6.38E-02	2	3	RRM2B, RRM2
	chromatin binding	1.69E-04	8.24E-02	12	516	ESR1, KAT6A, ASH1L, RELB, CBX4, KDM6B, ASH2L, PHF21A, TLE4, SMARCD3, H3F3B, CABIN1
Mouse Phenotype	increased immunoglobulin level	1.16E-06	2.92E-03	14	307	TRAF3IP2, GADD45B, SEMA4B, PSEN2, ESR1, SPTA1, ASH1L, BIRC3, RELB, MYSM1, CD4, PIK3C2A, RABGEF1, CABIN1
	abnormal humoral immune response	5.52E-06	1.39E-02	18	566	TRAF3IP2, GADD45B, SEMA4B, PSEN2, ESR1, SPTA1, MAP3K14, ASH1L, BIRC3, RELB, TNFRSF11A, MYSM1, CD4, PIK3C2A, CD38, RABGEF1, PAX5, CABIN1
	abnormal immunoglobulin level	7.68E-06	1.93E-02	17	522	TRAF3IP2, GADD45B, SEMA4B, PSEN2, ESR1, SPTA1, MAP3K14, ASH1L, BIRC3, RELB, TNFRSF11A, MYSM1, CD4, PIK3C2A, RABGEF1, PAX5, CABIN1
	increased IgG level	9.35E-06	2.35E-02	11	225	TRAF3IP2, GADD45B, SEMA4B, ESR1, SPTA1, ASH1L, BIRC3, MYSM1, CD4, PIK3C2A, CABIN1
	cortical renal glomerulopathies	1.18E-05	2.96E-02	10	188	TRAF3IP2, GADD45B, PSEN2, MYO1E, ESR1, SPTA1, RRM2B, ASH1L, RELB, PIK3C2A
	abnormal lymph node morphology	1.85E-05	4.66E-02	14	390	SELL, TRAF3IP2, TRAF1, PSEN2, ESR1, SPTA1, RRM2B, MAP3K14, BIRC3, RELB, TNFRSF11A, CD4, PIK3C2A, PIP
	glomerulonephritis	1.95E-05	4.91E-02	8	121	TRAF3IP2, GADD45B, PSEN2, ESR1, SPTA1, ASH1L, RELB, PIK3C2A
	abnormal B cell physiology	3.21E-05	8.07E-02	18	644	MYO1G, TRAF3IP2, GADD45B, SEMA4B, PSEN2, ESR1, SPTA1, MAP3K14, ASH1L, BIRC3, RELB, TNFRSF11A, MYSM1, CD4, PIK3C2A, RABGEF1, PAX5, CABIN1
Pathway	Signaling by Wnt	2.78E-06	2.47E-03	13	340	LGR4, ASH2L, FZD4, ARRB2, ZNRF3, TLE4, VPS35, H3F3B, AKT2, GNAO1, FZD2, MOV10, RAC3
	NF-kappa B signaling pathway	1.07E-04	9.44E-02	6	95	GADD45B, TRAF1, MAP3K14, BIRC3, RELB, TNFRSF11A
	Apoptosis	1.13E-04	9.97E-02	7	138	GADD45B, TRAF1, SEPT4, SPTA1, MAP3K14, BIRC3, AKT2

Functional enrichment results from ToppFun for Prefrontal Cortex Mega Module Cadetblue, where Bonferroni-corrected p<0.1.