MEMO Study 2011.

Methods	Study design: parallel RCT Study duration: September 2006 to April 2007 Follow‐up period: 18 months
Participants	Country: UK Setting: multicentre (primary care practices and specialist diabetes clinics in Leicestershire) Patients 25 to 80 years with type 2 diabetes and CKD stage 2 Number: treatment group (95); control group (95) Mean age ± SD (years): treatment group (62.6 ± 10.3); control group (60.3 ± 10.7) Sex (M/F): treatment group (71/24); control group (72/23) Exclusion criteria: history of malignancy, chronic liver disease or life expectancy < 5 years; learning disability/mental incapacity or immobility which precluded them from attending educational sessions; SCr > 180 mmol/L; participating in another research study
Interventions	Treatment group Intensive care + structured education program Control group Standard care
Outcomes	Mean HbA1c at 18 months BP Total and LDL cholesterol and urine albumin creatinine ratio Proportion of individuals reaching glycaemic, BP and lipid targets Modelled cardiovascular disease (UKPDS) risk scores
Notes	Funding source: government
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Insufficient information to permit judgement
Allocation concealment (selection bias)	Unclear risk	Insufficient information to permit judgement
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Insufficient information to permit judgement
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Data was recorded separately and assessed independently by a research physician who was not aware of the study participant’s treatment allocation and was not involved with any aspect of the study
Incomplete outcome data (attrition bias) All outcomes	Low risk	11/189 lost to follow‐up (6%)
Selective reporting (reporting bias)	Low risk	All expected outcomes reported
Other bias	Low risk	Study appears free of other biases