4. Diagnostic accuracy estimates for colour duplex ultrasound and contrast‐enhanced colour duplex ultrasound.

Imaging method	Summary sensitivity % (95% CI)	Summary specificity % (95% CI)	DOR (95% CI)	LR+ (95% CI)	LR‐ (95% CI)
Studies with accuracy estimates based on number of individual participants
CDUS (16 studies)	82 (66 to 91)	93 (87 to 96)	56 (19 to 164)	11.0 (6.0 to 20.0)	0.19 (0.100 to 0.39)
CE‐CDUS (11 studies)	94 (85 to 98)	95 (90 to 98)	299 (95 to 935)	19.5 (9.1 to 41.7)	0.07 (0.03 to 0.16)
Subgroup analysis 1: diagnostic performance of studies that estimated accuracy before and after administration of contrast (7 studies; analyses based on number of individual participants)
CDUS	67 (47 to 83)	94 (80 to 99)	35 (5 to 246)	12.0 (2.8 to 51.8)	0.34 (0.18 to 0.63)
CE‐CDUS	97 (92 to 99)	95 (85 to 98)	531 (131 to 2147)	17.7 (6.0 to 51.6)	0.03 (0.01 to 0.09)
Subgroup analysis 2: diagnostic performance of CE‐CDUS for type I and type III endoleaks
CE‐CDUS (7 studies)	97 (81 to 99)	99 (96 to 100)	7073 (254 to 196,804)	220.7 (25.9 to 1875.5)	0.031 (0.004 to 0.22)
Studies with accuracy estimates based on scan performed
CDUS (18 studies)	72 (55 to 85)	95 (90 to 96)	37 (16 to 87)	11.1 (6.8 to 18.1)	0.29 (0.17 to 0.51)
CE‐CDUS (8 studies)	91 (68 to 98)	89 (71 to 96)	77 (9 to 605)	8.2 (2.7 to 24.6)	0.11 (0.03 to 0.43)
Studies with accuracy estimates based on scan performed (excluding outliersMcWilliams 2002 and Nagre 2011)
CDUS (16 studies)	77 (64 to 87)	93 (89 to 96)	48 (21 to 110)	11.7 (6.8 to 20.0)	0.24 (0.14 to 0.41)
CE‐CDUS (6 studies)	93 (84 to 97)	91 (70 to 98)	125 (23 to 689)	9.9 (2.7 to 36)	0.08 (0.03 to 0.19)

CDUS: colour duplex ultrasound; CE‐CDUS: contrast‐enhanced colour duplex ultrasound; CI: confidence interval; DOR: diagnostic odds ratio; LR+: positive likelihood ratio; LR‐: negative likelihood ratio; NE: not estimable.