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. 2017 Jun 14;2017(6):CD011038. doi: 10.1002/14651858.CD011038.pub2

5. Overview of included studies.

  Intervention 1 Intervention 2 Foot ulcer grade Infection status at baseline Follow‐up Review‐relevant
outcomes with reportable data
Ahmed 2014 Group 1: (n = 30) Pyodine bath and saline and vaseline gauze dressing Group 2: (n = 30) Phenytoin powder Grade I or II Not reported 8 weeks None reported
Apelqvist 1996 Group 1: (n = 19) Gentamicin solution Group 2: (n = 22) Cadexomer iodine ointment Grade I or II Not reported 12 weeks

  1. Proportion of ulcers healed

  2. Surgical resection

  3. Adverse events
Bergqvist 2016 Group 1: (n = 19) Standard care Group 2: (n = 21) Chloramine plus standard care Not reported Infected 24 weeks

  1. Proportion of ulcers healed

  2. Resolution of infection

  3. Surgical resection
Bowling 2011 Group 1: (n = 10) Saline solution Group 2: (n = 10) Super‐oxidised aqueous solution Grade I or II Not infected 4 weeks

  1. Adverse events
Gottrup 2013 Group 1: (n = 15) Foam dressing Group 2: (n = 24) Silver collagen/oxidised regenerated cellulose dressing Grade II or III Not infected 14 weeks

  1. Proportion of ulcers healed

  2. Incidence of wound infection

  3. Adverse events
He 2016 Group 1: (n = 40) Routine debridement plus standard care (including blood glucose control, nutritional support, improve microcirculation Group 2: (n = 40) Silver ion dressing plus standard care Not reported Not reported 4 weeks

  1. Proportion of ulcers healed
Hwang 2010 Group 1: (n = not reported) Iodine gauze Group 2: (n = not reported) Hydrofiber dressing with silver Ulcers with bone and tendon exposure Not reported Not reported Not reported
Imran 2015 Group 1: (n = 180) Saline dressing Group 2: (n = 195) Honey dressing Grade I or II Not reported 17 weeks

  1. Proportion of ulcers healed

  2. Time to healing
Jacobs 2008 Group 1: (n = 20) Silver sulphadiazine cream Group 2: (n = 20) Formulation of benzoic acid, 6%; salicylic acid, 3%; and extract of oak bark (Quercus rubra), 3% (Bensal HP with QRB7), with silver sulphadiazine cream Grade I or II Not reported 6 weeks

  1. Proportion of ulcers healed
Jeffcoate 2009 Group 1: (n = 108) Non‐adherent dressing, viscose filament gauze
Group 2: (n = 103) Hydrocolloid (Hydrofiber) dressing		 Group 3: (n = 106) Iodine‐containing dressing Not reported Not reported 24 weeks

  1. Proportion of ulcers healed

  2. Health‐related quality of life (Cardiff Wound Impact Schedule and SF‐36)

  3. Surgical resection (amputations (minor and major))

  4. Adverse events (serious and non‐serious)
Jude 2007 Group 1: (n = 67) Calcium‐alginate dressing Group 2: (n = 67) Fibrous‐hydrocolloid (Hydrofiber) dressing with 1.2% ionic silver Grade I or II Mixed infected and not infected 8 weeks

  1. Proportion of ulcers healed

  2. Incidence of wound infection

  3. Adverse events
Khandelwal 2013 Group 1: (n = 20) Hyperbaric oxygen therapy (not considered further)
Group 2: (n = 20) Recombinant human platelet‐derived growth factor		 Group 3: (n = 20) Antiseptic treatments (EUSOL, hydrogen peroxide, and povidone iodine) Grade III or IV Not reported More than 8 weeks

  1. Proportion of ulcers healed
Landsman 2011 Group 1: (n = 21) Topical saline solution plus 750 mg levofloxacin once per day
Group 2: (n = 21) Super‐oxidised aqueous solution (topical Microcyn) alone (not considered)		 Group 3: (n = 21) super‐oxidised aqueous solution (topical Microcyn) therapy plus 750 mg levofloxacin once per day Eligible foot ulcers involved skin and deeper soft tissue Infected 4 weeks

  1. Resolution of infection

  2. Adverse events
Lipsky 2008a Group 1: (n = 246) Ofloxacin (200 mg) oral tablets and a topical placebo (vehicle) cream Group 2: (n = 247) Topical pexiganan cream (1% or 2%) and placebo oral tablets Not reported Infected Up to 42 days

  1. Surgical resection

  2. Adverse events
Lipsky 2008b Group 1: (n = 171) Ofloxacin (200 mg) oral tablets and a topical placebo (vehicle) cream Group 2: (n = 171) Topical pexiganan cream (1%) and placebo oral tablets Full‐thickness wounds Infected Up to 42 days

  1. Surgical resection

  2. Adverse events
Lipsky 2012a Group 1: (n = 38) Systemic antibiotic therapy alone Group 2: (n = 18) Daily topical application of the gentamicin‐collagen sponge combined with systemic antibiotic therapy Not reported Infected Up to 42 days

  1. Resolution of infection

  2. Adverse events
Martinez‐De Jesus 2007 Group 1: (n = 16) Povidone iodine and saline Group 2: (n = 21) Neutral pH super‐oxidised aqueous solution Not reported Infected 20 weeks

  1. Resolution of infection
Ramos Cuevas 2007 Group 1: (n = 25) Conventional treatment (no further details translated) Group 2: (n = 25) Zinc hyaluronate Not reported Unclear 20 weeks

  1. Proportion of ulcers healed
Shukrimi 2008
(30 participants randomised, but number in each group not specified)		 Group 1: Standard‐dressing group (povidone iodine solution 10%) (n not reported) Group 2: Honey dressing group (n not reported) Grade II Not reported Not reported No useable data
Tom 2005 Group 1: Normal saline solution, 11 ulcers (in 10 participants) Group 2: Tretinoin group, 13 ulcers (in 12 participants) Not reported Not reported 16 weeks

  1. Proportion of ulcers healed
Ullal 2014 Group 1: (n = 2) Povidone iodine and metronidazole 1% gel dressing Group 2: (n = 2) Honey and metronidazole 1% gel dressing Grade I and II Not reported Not reported

  1. Proportion of ulcers healed
Viswanathan 2011 Group 1: (n = 19) Polyherbal formulation Group 2: (n = 19) silver sulphadiazine cream Grade I, II, and III Unclear 20 weeks No useable data

Abbreviations: EUSOL, Edinburgh University Solution of Lime