| Study | Reason for exclusion |
|---|---|
| Abidia 2003 | Not relevant intervention (hyperbaric oxygen therapy) |
| Ajmeer 2015 | Not relevant study population (mixed wounds) |
| Al‐Ebous 2005 | Not relevant intervention (all antibiotics were administered intervenously) |
| Alzahrani 2013 | Not relevant study population |
| Bahar 2015 | Not RCT |
| Belcaro 2010 | Not relevant study population (mixed wound types) |
| Braumann 2008 | Not RCT |
| Braumann 2011 | Not RCT |
| Dalla Paola 2005 | Not RCT |
| Della Marchina 1997 | Not relevant study population (mixed wound types) |
| Driver 2015 | Not relevant intervention |
| Dwivedi 2007 | Not RCT |
| Gao 2007 | No outcome data available on request |
| Gibbons 2015 | Not RCT |
| Hadi 2007 | Not relevant study population |
| Kamaratos 2014 | Not RCT |
| Kapur 2011 | Not relevant study population |
| Kastelan 1998 | Not RCT |
| Li 2004 | Not relevant intervention |
| Li 2008 | Not relevant intervention (no topical treatment tested) |
| Li 2011 | Not relevant intervention |
| Lipsky 2015 | Not relevant intervention (no topical treatment tested) |
| Lishner 1985 | Not RCT |
| Londahl 2013 | Not relevant intervention (BioLight, combination of pulsating monochromatic light) |
| Lázaro‐Martínez 2014 | Not relevant intervention (no topical treatment tested) |
| Mahmoud 2008 | Not RCT |
| Martinez‐Sanchez 2005 | Not relevant intervention (ozone therapy) |
| Mikhaloĭko 2014 | Not relevant intervention (no topical treatment tested) |
| Minatel 2009 | Not relevant intervention (phototherapy) |
| Monami 2012 | Not relevant intervention (photosensitiser compound) |
| Morley 2012 | Not relevant intervention (cationic photosensitisers) |
| Motta 2004 | Not relevant study population (mixed wound types) |
| Münter 2006 | Not RCT |
| Otvos 2015 | Not RCT |
| Panahi 2015 | Not relevant study population (mixed population; only 18 diabetic patients included, separate data not available) |
| Paquette 2001 | Not RCT |
| Piaggesi 2010 | Not relevant study population |
| Reyzelman 2009 | Not relevant study population |
| Rhaiem 1998 | Not relevant study population (mixed population, number with diabetes and foot ulcers not reported) |
| Santomauro 2015 | Not relevant intervention |
| Scalise 2003 | Not RCT |
| Siavash 2011 | Not RCT |
| Siavash 2015 | Not RCT |
| Sibbald 2011 | Not relevant study population (mixed population, number with diabetes and foot ulcers not reported) |
| Song 2009 | Not RCT |
| Tardivo 2014 | Not RCT |
| Tauro 2013 | Not RCT |
| Tran 2014 | Not RCT |
| Trial 2010 | Not relevant study population (mixed population, data for people with diabetes and foot ulcers not available) |
| Uribe 2007 | Not RCT |
| Vandeputte 1997 | Antimicrobial treatment not the only systematic difference between trial arms |
| Varga 2014 | Not relevant study population |
| Wainstein 2011 | Not relevant intervention (ozone therapy) |
RCT: randomised controlled trial