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. 2017 Jun 29;2017(6):CD011412. doi: 10.1002/14651858.CD011412.pub2

Table 1.

Number of participants randomised to each drug

Trial\Drug CBZ PHB PHT VPS LTG OXC LEV TPM GBP ZNS Total Total
randomiseda
Trials providing individual participant data
Banu 2007 54 54 0 0 0 0 0 0 0 0 108 108
Baulac 2012 301 0 0 0 0 0 0 0 0 282 583 583
Bill 1997 0 0 144 0 0 143 0 0 0 0 287 287
Biton 2001 0 0 0 69 66 0 0 0 0 0 135 136
Brodie 1995a 66 0 0 0 70 0 0 0 0 0 136 136
Brodie 1995b 63 0 0 0 61 0 0 0 0 0 124 124
Brodie 1999 48 0 0 0 102 0 0 0 0 0 150 150
Brodie 2007 291 0 0 0 0 0 288 0 0 0 579 579
Chadwick 1998 74 0 0 0 0 0 0 0 218 0 292 292
Craig 1994 0 0 81 85 0 0 0 0 0 0 166 166
de Silva 1996 54 10 54 49 0 0 0 0 0 0 167 173
Dizdarer 2000 26 0 0 0 0 26 0 0 0 0 52 52
Eun 2012 41 0 0 0 43 0 0 0 0 0 84 84
Guerreiro 1997 0 0 94 0 0 99 0 0 0 0 193 193
Heller 1995 61 58 63 61 0 0 0 0 0 0 243 243
Kwan 2009 0 0 0 44 37 0 0 0 0 0 81 81
Lee 2011 53 0 0 0 57 0 0 0 0 0 110 110
Mattson 1985 155 155 165 0 0 0 0 0 0 0 475 475
Mattson 1992 236 0 0 244 0 0 0 0 0 0 480 480
Nieto‐Barrera 2001 202 0 0 0 420 0 0 0 0 0 622 622
Ogunrin 2005 19 18 18 0 0 0 0 0 0 0 55 55
Pal 1998 0 47 47 0 0 0 0 0 0 0 94 94
Placencia 1993 95 97 0 0 0 0 0 0 0 0 192 192
Privitera 2003 (CBZ branch)b 129 0 0 0 0 0 0 266 0 0 395 395
Privitera 2003 (VPS branch)b 0 0 0 78 0 0 0 147 0 0 225 225
Ramsey 1992 0 0 50 86 0 0 0 0 0 0 136 136
Ramsey 2010 0 0 128 0 0 0 0 133 0 0 261 261
Reunanen 1996 121 0 0 0 230 0 0 0 0 0 351 351
Richens 1994 151 0 0 149 0 0 0 0 0 0 300 300
SANAD A 2007 378 0 0 0 378 210 0 378 377 0 1721 1721
SANAD B 2007 0 0 0 238 239 0 0 239 0 0 716 716
Steiner 1999 0 0 95 0 86 0 0 0 0 0 181 181
Stephen 2007 0 0 0 109 117 0 0 0 0 0 226 227
Trinka 2013 (CBZ branch)b 503 0 0 0 0 0 493 0 0 0 996 999
Trinka 2013 (VPS branch)b 0 0 0 353 0 0 350 0 0 0 703 703
Turnbull 1985 0 0 70 70 0 0 0 0 0 0 140 140
Verity 1995 130 0 0 130 0 0 0 0 0 0 260 260
Werhahn 2015 121 0 0 0 118 0 122 0 0 0 361 361
Total 3372 439 1009 1765 2024 478 1253 1163 595 282 12,380 12,391
Trials not providing individual participant data
Trial\Drug CBZ PHB PHT VPS LTG OXC LEV TPM GBP ZNS Total Total
randomiseda
Aikia 1992 0 0 18 0 0 19 0 0 0 0 37 37
Bidabadi 2009 36 35 0 0 0 0 0 0 0 0 71 71
Brodie 2002 0 0 0 0 151 0 0 0 158 0 309 309
Callaghan 1985 59 0 58 64 0 0 0 0 0 0 181 181
Capone 2008 17 0 0 0 0 0 18 0 0 0 35 35
Castriota 2008 14 0 0 0 0 0 13 0 0 0 27 27
Chen 1996 26 25 0 25 0 0 0 0 0 0 76 76
Cho 2011 15 0 0 0 0 0 16 0 0 0 31 31
Christe 1997 0 0 0 121 0 128 0 0 0 0 249 249
Consoli 2012 66 0 0 0 0 0 62 0 0 0 128 128
Cossu 1984 6 6 0 0 0 0 0 0 0 0 12 12
Czapinski 1997 30 30 30 30 0 0 0 0 0 0 120 120
Dam 1989 100 0 0 0 0 94 0 0 0 0 194 194
Donati 2007 28 0 0 29 0 55 0 0 0 0 112 112
Feksi 1991 152 150 0 0 0 0 0 0 0 0 302 302
Forsythe 1991 23 0 20 21 0 0 0 0 0 0 64 64
Fritz 2006 0 0 0 0 21 27 0 0 0 0 48 48
Gilad 2007 32 0 0 0 32 0 0 0 0 0 64 64
Jung 2015 64 0 0 0 0 0 57 0 0 0 121 121
Kalviainen 2002 70 0 0 0 73 0 0 0 0 0 143 143
Kopp 2007 6 0 0 3 0 0 6 0 0 0 15 15
Korean Lamotrigine Study Group 2008 129 0 0 0 264 0 0 0 0 0 393 393
Lukic 2005 0 0 0 38 35 0 0 0 0 0 73 73
Mitchell 1987 15 18 0 0 0 0 0 0 0 0 33 33
Miura 1990 66 0 51 46 0 0 0 0 0 0 163 163
Motamedi 2013 0 0 0 0 50 0 50 0 0 0 100 100
NCT01498822 0 0 0 0 0 178 175 0 0 0 353 353
NCT01954121 215 0 0 0 0 0 218 0 0 0 433 433
Pulliainen 1994 23 0 20 0 0 0 0 0 0 0 43 43
Ramsey 1983 42 0 45 0 0 0 0 0 0 0 87 87
Ramsey 2007c ? 0 0 0 0 0 ? 0 0 0 37 37
Rastogi 1991 0 0 45 49 0 0 0 0 0 0 94 94
Ravi Sudhir 1995 20 0 20 0 0 0 0 0 0 0 40 40
Resendiz 2004 42 0 0 0 0 0 0 46 0 0 88 88
Rowan 2005 198 0 0 0 200 0 0 0 195 0 593 593
Saetre 2007 92 0 0 0 93 0 0 0 0 0 185 185
Shakir 1981 0 0 15 18 0 0 0 0 0 0 33 33
So 1992 17 0 0 16 0 0 0 0 0 0 33 33
Suresh 2015 30 0 0 0 0 0 30 0 0 0 60 60
Steinhoff 2005 88 0 0 30 121 0 0 0 0 0 239 239
Thilothammal 1996 0 51 52 48 0 0 0 0 0 0 151 151
Totalc 1721 315 374 538 1040 501 645 46 353 0 5570 5570
Grand totalc 5093 754 1383 2303 3064 979 1898 1209 948 282 17,950 17,961

CBZ: carbamazepine; GBP: gabapentin; IPD: individual participant data; ITT: intention to treat; LEV: levetiracetam; LTG: lamotrigine; OXC: oxcarbazepine; PHB: phenobarbitone; PHT: phenytoin; TPM: topiramate; VPS: sodium valproate; ZNS: zonisamide

aDrug allocated missing for 11 participants in the IPD provided. bTrials designed in two strata based on whether recommended treatment would be CBZ or VPS. Within the two strata, participants were randomised to TPM in Privitera 2003/LEV in Trinka 2013 or CBZ/VPS depending on the strata. Data analysed according to the separate strata (CBZ branch or VPS branch) in this review. cOne trial provided the total number randomised but not the numbers randomised to each group. The 37 participants randomised are counted in the overall totals.